Opioid-induced constipation in palliative care: state of the art / Constipação induzida por opióides em cuidado paliativo: o estado da arte

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Erlania do Carmo Freitas
Geslaney Reis da Silva
Rudval Souza da Silva
Rita Narriman Silva de Oliveira Boery
Maria Patricia Milagres


OBJECTIVE: The study’s purpose has been to address the state of the art in investigations such as clinical trials, systematic reviews with meta-analysis and case studies, which report how to minimize opioid-induced constipation in patients undergoing palliative care. METHODS: This is an exploratory study through an integrative review of four databases addressing published articles from 2013 to 2017. RESULTS: A total of 117 publications were presented, which 17 presented the inclusion criteria. The studies describe the prevalence of constipation rates induced by the use of opioids. CONCLUSION: Although these drugs alleviate pain, the adverse reactions may generate discomfort and loss of the patient’s life quality. There are limited data on the treatment of constipation. It was observed that few authors mentioned diet as a helper on this situation, emphasizing the use of medications. Further studies should be encouraged aiming to find the balance between analgesia and reduction of adverse effects.


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do Carmo Freitas E, da Silva GR, Souza da Silva R, Narriman Silva de Oliveira Boery R, Patricia Milagres M. Opioid-induced constipation in palliative care: state of the art / Constipação induzida por opióides em cuidado paliativo: o estado da arte. R. pesq. cuid. fundam. online [Internet]. 1º de maio de 2021 [citado 21º de março de 2023];12:1116-24. Disponível em: http://seer.unirio.br/cuidadofundamental/article/view/8008
Integrative Review of the Literature
Biografia do Autor

Erlania do Carmo Freitas, Universidade Estadual do Sudoeste da Bahia - UESB

Nutricionista, doutoranda em Enfermagem e Saúde - UESB

Geslaney Reis da Silva, Universidade Estadual do Sudoeste da Bahia

Enfermeiro. Mestre em Ciências da Saúde pelo Programa de Pós-Graduação em Enfermagem e Saúde, Universidade Estadual do Sudoeste da Bahia (UESB).

Rita Narriman Silva de Oliveira Boery, Universidade Estadual do Sudoeste da Bahia - UESB

Professora pleno, Doutora do programa de pós-graduação em Enfermagem e saúde

Maria Patricia Milagres, Universidade Estadual do Sudoeste da Bahia - UESB

Doutora Professora Adjunta da Universidade Estadual do Sudoeste da Bahia - UESB

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