EL EFECTO DE LOS ENFOQUES HERBALES EN LA MUCOSITIS ORAL EN INDIVIDUOS ADULTOS CON CÁNCER - UNA REVISIÓN SISTEMÁTICA DE ESTUDIOS DE ENFERMERÍA
DOI:
https://doi.org/10.9789/2175-5361.rpcfo.v16.13234Palabras clave:
Síntomas cancerígenos, estomatitis, herbario, enfermería oncológica, revisión sistemáticaResumen
Objetivo: examinar los efectos de los enfoques herbales en la mucositis oral en pacientes adultos con cáncer. Método: revisión sistemática siguiendo las directrices de Cochrane, con una búsqueda de estudios experimentales y aleatorizados entre 2013 y 2023. Se incluyeron estudios en inglés sobre intervenciones herbales en pacientes mayores de 18 años. Resultados: se evaluaron ocho estudios que utilizaron intervenciones herbales para tratar la mucositis oral. Las hierbas probadas incluyeron aloe vera, raíz de althaea, cúrcuma, manzanilla, vinagre de uva, agua de rosas, jugo de frutas/verduras y extracto de moras. Las intervenciones variaron en frecuencia y duración, pero mostraron resultados positivos, reduciendo la intensidad de la mucositis oral, el dolor y otros síntomas. Algunas intervenciones fueron tan eficaces como tratamientos convencionales como la clorhexidina. Conclusión: la investigación sugiere que los enfoques herbales pueden ser beneficiosos para el manejo de la mucositis oral en pacientes con cáncer, pero se necesitan más estudios para confirmar estos resultados.
Descargas
Citas
ArbabiSarjou A, Khamar M, Sasanpour P, Kiani F. The Effect of Self-Care Training on the Severity of Oral Mucositis in Breast Cancer Patients Undergoing Chemotherapy. Med-Surg Nurs J. 2021;10(4):e123386. DOI: 10.5812/msnj.123386
World Health Organization (WHO). Cancer [Internet]. 2019 [April 12, 2023]. Accessed: https://www.who.int/health-topics/cancer
Mohammadi F, Oshvandi K, Kamallan SR, Khazaei S, Ranjbar H, Ahmadi‐Motamayel F, vd. Effectiveness of Sodium Bicarbonate and Zinc Chloride Mouthwashes in the Treatment of Oral Mucositis and Quality of Life in Patients with Cancer Under Chemotherapy. Nurs Open. Mayıs 2022;9(3):1602-11. DOI: 10.1002/nop2.1168
Global World Cancer Research Fund International. Global Cancer Data by country [Internet]. 2023 [April 12, 2023]. Accessed: https://www.wcrf.org/cancer-trends/global-cancer-data-by-country/
Askarifar M, Lakdizaji S, Ramzi M, Rahmani A, Jabbarzadeh F. The Effects of Oral Cryotherapy on Chemotherapy-Induced Oral Mucositis in Patients Undergoing Autologous Transplantation of Blood Stem Cells: A Clinical Trial. Iran Red Crescent Med J. 2016;18(4):e24775. DOI: 10.5812/ircmj.24775
Ali YM, El–Kady MS, Ali HS, Abdelatief DAA, Abdelslam SN. Effect of Educational Guidelines on Reducing Chemotherapy Induced Oral Mucositis Based on Patients’ Needs Assessment. Int J Res Pharm Sci. 2020;11(SPL4):2570-4. DOI: 10.26452/ijrps.v11iSPL4.4514
Kostak MA, Semerci̇ R, Eren T, Kocaaslan EN, Yıldız F. Effects of Oral Health Care Education on the Severity of Oral Mucositis in Pediatric Oncology Patients. Turk J Oncol. 2020;35(4):422-9. DOI: 10.5505/tjo.2020.2366
Ghorbani F, Yazdanian M, Tahmasebi E, Izadi M, Mofid B, Varpaei HA. Effect of Ozonated Water on Oral Mucositis and Pain Induced by Head and Neck Radiotherapy: A Cross-Sectional Study. Arch Neurosci. 2021;8(4):e118914. DOI: 10.5812/ans.118914
Afrasiabifar A, Dekhordi NJ, Mosavi A, Mozaffari MAN, Bani ZAB. Oral Mucositis: Examining the Combined Solution of Grape Vinegar and Rose Water Versus Chlorhexidine Mouthwash. Clin J Oncol Nurs. 2020;24(6):E71-8. DOI: 10.1188/20.CJON.E71-E78
Avcı Ş, Sarı HY. Effect of an Evidence-Based Nursing Intervention on the Diagnosis of Oral Mucositis in the Pediatric Stem Cell Transplant Unit. Asia-Pac J Oncol Nurs. 2019;6(3):292-9. DOI: 10.4103/apjon.apjon_5_19
Toygar I, Yeşilbalkan ÖU. Determining the Non-Pharmacological Methods Using to Cope with Radiation-Related Oral Mucositis in Patients with Head and Neck Cancer. Nurs Pract Today. 2019;6(3):116-22. https://publish.kne-publishing.com/index.php/NPT/article/view/1254
Bai RR. Effectiveness of Oral Ice Cube Application on Prevention of Oral Mucositis Among Cancer Patients Who Receive Chemotherapy. Innov J Nurs Heal. 2019;5(3):38-43. DOI: 10.31690/ijnh/39
Chan CWH, Law BMH, Wong MMH, Chan DNS, Ng MSN, So WKW, vd. Oral Mucositis Among Chinese Cancer Patients Receiving Chemotherapy: Effects and Management Strategies. Asia Pac J Clin Oncol. Nisan 2021;17(2):e10-7. DOI: 10.1111/ajco.13349
Ghorbani MS, Taghadosi M, Shariat A, Akbari H. Effects of Althaea Root Extract on Alleviating Chemotherapy-Induced Stomatitis Pain: A Randomized Controlled Clinical Trial. J Client-Centered Nurs Care. 2018;4(1):37-44. https://www.sid.ir/FileServer/JE/50002120180105
Karabey T, Karagözoğlu Ş, Aygün N, Sümer Z. The Effect of Oral Care with Black Mulberry Extract on Oral Mucositis, Dry Mouth, and Weight Gain in Patients with Cancer. Clin J Oncol Nurs. 2022;26(6):636-42. DOI: 10.1188/22.CJON.636-642
Chang HP, Huang MC, Lei YP, Chuang YJ, Wang CW, Sheen LY. Phytochemical-Rich Vegetable and Fruit Juice Alleviates Oral Mucositis During Concurrent Chemoradiotherapy in Patients with Locally Advanced Head and Neck Cancer. J Tradit Complement Med. 2022;12(5):488-98. DOI: 10.1016/j.jtcme.2022.03.004
Ghorbani MS, Taghadosi M, Akbari H, Sharifi M. Effect of Hydroalcoholic Extract of Althaea Officinalis Root on Improving Chemotherapy-Induced Stomatitis: A Randomized, Double-Blind, Clinical Trial. Nurs Midwifery Stud. 2019;8(1):14-20. DOI: 10.4103/nms.nms_42_18
AbdElwadoud AM, Hassanein SM, El-Deen DS, Abdou I. Using Chamomile for Alleviating Oral Mucositis Among Patients with Head and Neck Cancer Receiving Radiotherapy. Egypt Nurs J. 2019;16(3):186. DOI: 10.4103/ENJ.ENJ_12_20
Lalla RV, Bowen J, Barasch A, Elting L, Epstein J, Keefe DM, vd. MASCC/ISOO Clinical Practice Guidelines for the Management of Mucositis Secondary to Cancer Therapy. Cancer. 2020;120(10):1453-61. DOI: 10.1002/cncr.28592
Kara H, Arıkan F, Kartöz F, Şahin AFK. Nurse-Led Oral Mucositis Management: Impact on Health Outcomes of Patients Receiving Radiotherapy for Head and Neck Cancer and Lung Cancer: A Prospective Study. 2022; DOI: 10.21203/rs.3.rs-1734361/v1
Harman M, Ovayolu N, Ovayolu ÖU. The Effect of Three Different Solutions on Preventing Oral Mucositis in Cancer Patients Undergoing Stem Cell Transplantation: A Non-Randomized Controlled Trial: A Turkish Study. J Pak Med Assoc. 2019;69(6):811-6. https://acikerisim.medipol.edu.tr/xmlui/handle/20.500.12511/776
Badr LK, El Asmar R, Hakim S, Saad R, Merhi R, Zahreddine A, vd. The Efficacy of Honey or Olive Oil on the Severity of Oral Mucositis and Pain Compared to Placebo (standard Care) in Children with Leukemia Receiving Intensive Chemotherapy: A Randomized Controlled Trial (RCT). J Pediatr Nurs. 2023;70:e48-53. DOI: 10.1016/j.pedn.2022.12.003
Ambili R, Ramadas K, Nair LM, Raj D, Nazeer F, George PS, vd. Efficacy of a Herbal Mouthwash for Management of Periodontitis and Radiation-Induced Mucositis–a Consolidated Report of Two Randomized Controlled Clinical Trials. J Ayurveda Integr Med. 2023;14(6):100791. DOI: 10.1016/j.jaim.2023.100791
Safarzadeh S, Shirban F, Bagherniya M, Sathyapalan T, Sahebkar A. The Effects of Herbal Medicines on Cancer Therapy Oral Mucositis: A Literature Review. Phytother Res. Ocak 2022;36(1):243-65. DOI: 10.1002/ptr.7308
Baharvand M, Jafari S, Mortazavi H. Herbs in Oral Mucositis. J Clin Diagn Res JCDR. 2017;11(3):ZE05. DOI: 10.7860/JCDR/2017/21703.9467
Cochrane Library. Cochrane Handbook for Systematic Reviews of Interventions [Internet]. 2023 [April 15, 2023]. Accessed: https://training.cochrane.org/handbook/current
Cochrane Library. Rob 2: A Revised Cochrane Risk-of-Bias Tool for Randomized Trials | Cochrane Bias [İnternet]. 2019 [December 1, 2023]. Accessed: https://methods.cochrane.org/bias/resources/rob-2-revised-cochrane-risk-bias-tool-randomized-trials
Kalav S, Çetin AA, Bektaş H. The Effect of Oral Hygiene Practices in Patients with Stroke: Systematic Review. Turk Klin J Nurs Sci. 2020;12(3). DOI: 10.5336/nurses.2020-74729
Mansouri P, Haghighi M, Beheshtipour N, Ramzi M. The Effect of Aloe Vera Solution on Chemotherapy-Induced Stomatitis in Clients with Lymphoma and Leukemia: A Randomized Controlled Clinical Trial. Int J Community Based Nurs Midwifery. 2016;4(2):119. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876780/
David MPR, Shree MKT. Effectiveness of Turmeric Mouthwash and Sodium Bicarbonate Mouthwash to Reduce Oral Mucositis among Patient Undergoing Radiation Therapy. Sch Int J Tradit Complement Med. 2019;2(7):124-7. DOI: 10.36348/SIJTCM.2019.v02i07.001
McCaffery M, Beebe A. The Numeric Pain Rating Scale Instructions. Pain Clin Man Nurs Pract. 1989 http://nperesource.casn.ca/wp-content/uploads/2017/02/Numeric-Pain-Rating-Scale-Instructions.pdf
Bjarnason GA, MacKenzie RG, Nabid A, Hodson ID, El-Sayed S, Grimard L, vd. Comparison of Toxicity Associated with Early Morning Versus Late Afternoon Radiotherapy in Patients with Head-and-Neck Cancer: A Prospective Randomized Trial of the National Cancer Institute of Canada Clinical Trials Group (HN3). Int J Radiat Oncol Biol Phys. 2009;73(1):166-72. DOI: 10.1016/j.ijrobp.2008.07.009
Kushner JA, Lawrence HP, Shoval I, Kiss TL, Devins GM, Lee L, vd. Development and Validation of a Patient-Reported Oral Mucositis Symptom (PROMS) Scale. J Can Dent Assoc. 2008;74(1):p59-59j. https://search.ebscohost.com/login.aspx?direct=true&profile=ehost&scope=site&authtype=crawler&jrnl=07098936&AN=30006141&h=90yvGQW9sUKXaPJ%2Fbfdg%2FgBlUbQYIiOfyH6m%2FAD1NtS3OzXHILHi2%2FQGeiNzQmy7%2B8LDX0X%2FMlxE%2FP4iQx5Ijg%3D%3D&crl=c
Bjordal K, Ahlner-Elmqvist M, Tollesson E, Jensen AB, Razavi D, Maher EJ, vd. Development of a European Organization for Research and Treatment of Cancer (EORTC) Questionnaire Module to be Used in Quality of Life Assessments in Head and Neck Cancer Patients. Acta Oncol. Ocak 1994;33(8):879-85. DOI: 10.3109/02841869409098450
Eilers J, Berger AM, Petersen MC. Development, Testing, and Application of the Oral Assessment Guide. Oncology Nursing Society; 1988; p.325-30. https://experts.nebraska.edu/en/publications/development-testing-and-application-of-the-oral-assessment-guide
Guberti M, Botti S, Caffarri C, Cavuto S, Savoldi L, Fusco A, vd. Efficacy and Safety of a Colostrum- and Aloe Vera-Based Oral Care Protocol to Prevent and Treat Severe Oral Mucositis in Patients Undergoing Hematopoietic Stem Cell Transplantation: A Single-Arm Phase Ii Study. Ann Hematol. Ekim 2022;101(10):2325-36. DOI: 10.1007/s00277-022-04934-4
Alkhouli M, Laflouf M, Alhaddad M. Efficacy of Aloe-Vera Use for Prevention of Chemotherapy-Induced Oral Mucositis in Children with Acute Lymphoblastic Leukemia: A Randomized Controlled Clinical Trial. Compr Child Adolesc Nurs. 02 Ocak 2021;44(1):49-62. DOI: 10.1080/24694193.2020.1727065
Karbasizade S, Ghorbani F, Darestani NG, Mansouri-Tehrani MM, Kazemi AH. Comparison of Therapeutic Effects of Statins and Aloe Vera Mouthwash on Chemotherapy Induced Oral Mucositis. Int J Physiol Pathophysiol Pharmacol. 2021;13(4):110. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446774/
Sahebjamee M, Mansourian A, Hajimirzamohammad M, Zadeh MT, Bekhradi R, Kazemian A, vd. Comparative Efficacy of Aloe Vera and Benzydamine Mouthwashes on Radiation-Induced Oral Mucositis: A Triple-Blind, Randomised, Controlled Clinical Trial. Oral Health Prev Dent. 2015;13(4):309-15. DOI: 10.3290/j.ohpd.a33091
Normando AGC, De Menêses AG, De Toledo IP, Borges GÁ, De Lima CL, Dos Reis PED, vd. Effects of Turmeric and Curcumin on Oral Mucositis: A Systematic Review. Phytother Res. Mayıs 2019;33(5):1318-29. DOI: 10.1002/ptr.6326
Soni TP, Gupta AK, Sharma LM, Singhal H, Sharma S, Gothwal RS. A Randomized, Placebo-Controlled Study to Evaluate the Effect of Bio-Enhanced Turmeric Formulation on Radiation-Induced Oral Mucositis. Orl. 2022;84(2):103-13. DOI: 10.1159/000516577
Thomas PL, Kang HK, Rishi KS. Randomized Control Study of the Effects of Turmeric Mouthwash on Oral Health Status, Treatment-Induced Mucositis, and Associated Oral Dysfunctions Among Patients with Head and Neck Cancer. Cancer Nurs. 2023;46(1):36-44. DOI: 10.1097/NCC.0000000000001149
Elhadad MA, El‐Negoumy E, Taalab MR, Ibrahim RS, Elsaka RO. The Effect of Topical Chamomile in the Prevention of Chemotherapy‐Induced Oral Mucositis: A Randomized Clinical Trial. Oral Dis. Ocak 2022;28(1):164-72. DOI: 10.1111/odi.13749
Reis PEDD, Ciol MA, de Melo NS, Figueiredo PT de S, Leite AF, Manzi N de M. Chamomile Infusion Cryotherapy to Prevent Oral Mucositis Induced by Chemotherapy: A Pilot Study. Support Care Cancer. 2016;24:4393-8. DOI: 10.1007/s00520-016-3279-y
Ameri A, Heydarirad G, Choopani R, Poshtmahi S, Ameri P, Talebi F, vd. Sumac-Rose Water Mouthwash Versus Benzydamine to Prevent Radiation-Induced Oral Mucositis in Head and Neck Cancers: A Phase Ii Randomized Trial. J Cancer Res Clin Oncol. 2023;1-13. DOI: 10.1007/s00432-023-04687-1
Korkut S, Karadağ S, Çınar SL. The Effect of Oral Care with Black Mulberry Syrup on Oral Mucositis in Patients with COPD: A Mixed Study. Altern Ther. 2021. http://www.alternative-therapies.com/oa/pdf/6430.pdf
Doğan P, Tarhan M, Kürklü A. Effectiveness of Black Mulberry Molasses in Prevention of Radiotherapy-Induced Oral Mucositis: A Randomized Controlled Study in Head and Neck Cancer Patients. The Journal of Alternative and Complementary Medicine. 2023;11(2):1591-602. DOI: 10.1089/acm.2016.0425
Fischer L. Black Mulberry Extract Shows Efficacy in Oral Mucositis Management for Patients Receiving Chemotherapy. Oncol Nurs News. 2022;NA-NA. https://go.gale.com/ps/i.do?p=HRCA&sw=w&issn=&v=2.1&it=r&id=GALE%7CA762612137&sid=googleScholar&linkaccess=abs
Sarı SY, Beduk Esen CS, Yazici G, Yuce D, Cengiz M, Ozyigit G. Do Grape and Black Mulberry Molasses Have an Effect on Oral Mucositis and Quality of Life in Patients with Head and Neck Cancer? Support Care Cancer. 2022;30:327-36. DOI: 10.1007/s00520-021-06411-6
Ebrahim AA, Ahmed ES, Eltayeb AA, Sayed EH. Role of Chlorhexidine in Preventing Mucositis Among Ventilated Children at Pediatric Intensive Care Unit. Assiut Sci Nurs J. 2022;10(28.):123-34. DOI: 10.21608/ASNJ.2022.121442.1323
Publicado
Versiones
- 2024-09-06 (4)
- 2024-07-22 (3)
- 2024-07-18 (2)
- 2024-07-10 (1)
Cómo citar
Número
Sección
Licencia
Derechos de autor 2024 Revista de Pesquisa Cuidado é Fundamental Online
Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-CompartirIgual 4.0.
TERMO DE TRANSFERÊNCIA DE DIREITOS AUTORAIS
Transfiro os direitos autorais deste artigo para a Revista de Pesquisa Cuidado é Fundamental - Online - RPCF, assim que ele for aceito para a devida publicação eletrônica. Os direitos de autor incluem o direito de reproduzir na íntegra ou em parte por qualquer meio, distribuir o referido artigo, incluindo figuras, fotografias, bem como as eventuais traduções. O autor pode ainda, imprimir e distribuir cópias do seu artigo, desde que mencione que os direitos pertencem a RPCF. Declaro que este manuscrito é original, não tendo sido submetido à publicação, na íntegra ou em partes para outros periódicos online ou não, assim cmmo em Anais de eventos científicos ou capítulos de livros.