La melatonina como tratamiento para pacientes con síndrome metabólico
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https://doi.org/10.9789/2175-5361.rpcfo.v17.14086Palabras clave:
Uso terapêuticoResumen
Objetivo: el estudio tuvo como objetivo evaluar el uso de melatonina como tratamiento para pacientes con Síndrome Metabólico. Método: se realizó una revisión sistemática de la literatura, buscando en cuatro bases de datos estudios publicados de 2014 a 2024, siguiendo la estrategia PICO y las recomendaciones de la declaración PRISMA. Se incluyeron ensayos clínicos aleatorizados, sin restricciones de idioma, que evaluaran la intervención con melatonina en pacientes con Síndrome Metabólico. Resultados: inicialmente, se identificaron 132 registros. Después de la evaluación metodológica, se incluyeron en la revisión 3 artículos. Los estudios incluidos abordaron la suplementación con melatonina en pacientes con Síndrome Metabólico, mostrando resultados prometedores con respecto a los marcadores de estrés oxidativo y componentes metabólicos. Algunos estudios presentaron limitaciones en los dominios "Poder", "Validez externa" e "Informes" de Downs y Black. Conclusión: la melatonina demostró potencial terapéutico en el tratamiento del Síndrome Metabólico con efectos antioxidantes y acción sobre parámetros metabólicos.
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Alberti KGMM, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, et al. Harmonizing the Metabolic Syndrome: A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. [Internet]. 2009 [cited 2024 jun 05];120(16). Available from: https://doi.org/10.1161/circulationaha.109.192644.
Oliveira LVA, Santos BNSD, Machado ÍE, Malta DC, Velasquez-Melendez G, Felisbino-Mendes MS. Prevalence of the Metabolic Syndrome and its components in the Brazilian adult population. Ciên. Saúde Colet. [Internet]. 2020 [cited 2024 jun 05];25(11). Available from: https://doi.org/10.1590/1413-812320202511.31202020.
Liang M, Pan Y, Zhong T, Zeng Y, Cheng ASK. Effects of aerobic, resistance, and combined exercise on metabolic syndrome parameters and cardiovascular risk factors: a systematic review and network meta-analysis. Rev. Cardiovasc. Med. [Internet]. 2021 [cited 2024 jun 05];22(4). Available from: https://doi.org/10.31083/j.rcm2204156.
Di Cesare M, Perel P, Taylor S, Kabudula C, Bixby H, Gaziano TA, et al. The Heart of the World. Glob. Heart. [Internet]. 2024 2021 [cited 2024 jun 10];19(1). Available from: https://doi.org/10.5334/gh.1288.
Reiter RJ, Tan DX, Korkmaz A, Ma S. Obesity and metabolic syndrome: Association with chronodisruption, sleep deprivation, and melatonin suppression. Ann. Med. [Internet]. 2012 [cited 2024 jun 10];44(6). Available from: https://doi.org/10.3109/07853890.2011.586365.
Minich DM, Henning M, Darley C, Fahoum M, Schuler CB, Frame J. Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements. Nutrients. [Internet]. 2022 [cited 2024 jun 10];14(19). Available from: https://doi.org/10.3390/nu14193934.
Miola A, Fornaro M, Sambataro F, Solmi M. Melatonin and melatonin-agonists for metabolic syndrome components in patients treated with antipsychotics: A systematic review and meta-analysis. Hum. Psychopharmacol. [Internet]. 2022 [cited 2024 jun 10];37(2):e2821. Available from: https://doi.org/10.1002/hup.2821.
Guerra J, Devesa J. Melatonin Exerts Anti-Inflammatory, Antioxidant, and Neuromodulatory Effects That Could Potentially Be Useful in the Treatment of Vertigo. Int. J. Otolaryngol. [Internet]. 2021 [cited 2024 jun 15];2021:6641055. Available from: https://doi.org/10.1155/2021/6641055.
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. [Internet]. 2021 [cited 2024 jun 15];372(71). Available from: https://doi.org/10.1136/bmj.n71.
Sharma N, Srivastav AK, Samuel AJ. Ensaio clínico randomizado: padrão ouro de desenhos experimentais - importância, vantagens, desvantagens e preconceitos. Rev. Pesqui. Fisioter. [Internet]. 2020[acesso em 15 de junho 2024];10(3). Disponível em: https://doi.org/10.17267/2238-2704rpf.v10i3.3039.
Williams CYK, Townson AT, Kapur M, Ferreira AF, Nunn R, Galante J, et al. Interventions to reduce social isolation and loneliness during COVID-19 physical distancing measures: A rapid systematic review. PLoS One. [Internet]. 2021 [cited 2024 jun 15];16(2):e0247139. Available from: https://doi.org/10.1371/journal.pone.0247139.
PRISMA 2020 flow diagram. PRISMA statement. [Internet]. 2020 [cited 2024 jul 22]. Available from: https://www.prisma-statement.org/prisma-2020-flow-diagram.
Ghaderi-Zefrehi H, Seif F, Niayesh‐Mehr R, Ayashi S, Jafarirad S, Niknam Z, et al. Impact of the supplementation of melatonin on oxidative stress marker and serum endothelin-1 in patients with metabolic syndrome. Int. J. Diabetes Dev. Ctries. [Internet]. 2023 [cited 2024 may 12]; Available from: https://doi.org/10.1007/s13410-023-01266-5.
Abood SJ, Abdulsahib WK, Hussain SA, Ismail SH. Melatonin Potentiates the Therapeutic Effects of Metformin in Women with Metabolic Syndrome. Sci. Pharm. [Internet]. 2020 [cited 2024 may 12];88(2). Available from: https://doi.org/10.3390/scipharm88020028.
Goyal A, Terry PD, Superak HM, Nell-Dybdahl CL, Chowdhury R, Phillips LS, et al. Melatonin supplementation to treat the metabolic syndrome: a randomized controlled trial. Diabetol. Metab. Syndr. [Internet]. 2014 [cited 2024 may 12];6(1). Available from: https://doi.org/10.1186/1758-5996-6-124.
Hohor S, Mandanach C, Maftei A, Zugravu CA, Oțelea MR. Impaired Melatonin Secretion, Oxidative Stress and Metabolic Syndrome in Night Shift Work. Antioxidants. [Internet]. 2023 [cited 2024 may 12];12(4). Available from: https://doi.org/10.3390/antiox12040959.
Javid AZ, Hosseini SA, Gholinezhad H, Moradi L, Haghighi-zadeh MH, Bazyar H. Antioxidant and Anti-Inflammatory Properties of Melatonin in Patients with Type 2 Diabetes Mellitus with Periodontal Disease Under Non-Surgical Periodontal Therapy: A Double-Blind, Placebo-Controlled Trial. Diabetes Metab. Syndr. Obes. [Internet]. 2020 [cited 2024 may 12];13. Available from: https://doi.org/10.2147/dmso.s242208.
Esalatmanesh K, Loghman A, Esalatmanesh R, Soleimani Z, Khabbazi A, Mahdavi et al. Effects of melatonin supplementation on disease activity, oxidative stress, inflammatory, and metabolic parameters in patients with rheumatoid arthritis: a randomized double-blind placebo-controlled trial. Clin. Rheumatol. [Internet]. 2021 [cited 2024 may 12];40(9). Available from: https://doi.org/10.1007/s10067-021-05670-2.
Satari M, Bahmani F, Reiner Z, Soleimani A, Aghadavod E, Kheiripour N, et al. Metabolic and Anti-inflammatory Response to Melatonin Administration in Patients with Diabetic Nephropathy. Iran J. Kidney Dis. [Internet]. 2021 [cited 2024 may 12];1(1). Available from: https://ijkd.org/index.php/ijkd/article/view/5421/1240.
Ostadmohammadi V, Soleimani A, Bahmani F, Aghadavod E, Ramezani R, Reiter RJ, et al. The Effects of Melatonin Supplementation on Parameters of Mental Health, Glycemic Control, Markers of Cardiometabolic Risk, and Oxidative Stress in Diabetic Hemodialysis Patients: A Randomized, Double-Blind, Placebo-Controlled Trial. J. Ren. Nutr. [Internet]. 2020 [cited 2024 may 12];30(3). Available from: https://doi.org/10.1053/j.jrn.2019.08.003.
Overberg J, Kalveram L, Keller T, Krude H, Kühnen P, Wiegand S. Interactions between nocturnal melatonin secretion, metabolism, and sleeping behavior in adolescents with obesity. Int. J. Obes. [Internet]. 2022 [cited 2024 may 20];46(5). Available from: https://doi.org/10.1038/s41366-022-01077-4.
Genario R, Cipolla-Neto J, Bueno AA, Santos HO. Melatonin supplementation in the management of obesity and obesity-associated disorders: A review of physiological mechanisms and clinical applications. Pharmacol. Res. [Internet]. 2021 [cited 2024 may 20];163:105254. Available from: https://observatorio.fm.usp.br/handle/OPI/40015.
Peneva VM, Terzieva DD, Mitkov MD. Role of Melatonin in the Onset of Metabolic Syndrome in Women. Biomedicines. [Internet]. 2023 [cited 2024 may 20];11(6). Available from: https://doi.org/10.3390/biomedicines11061580.
Singhanat K, Apaijai N, Sumneang N, Maneechote C, Arunsak B, Chunchai T, et al. Therapeutic potential of a single-dose melatonin in the attenuation of cardiac ischemia/reperfusion injury in prediabetic obese rats. Cell. Mol. Life Sci. [Internet]. 2022 [cited 2024 may 20];79(6). Available from: https://doi.org/10.1007/s00018-022-04330-1.
Li Y, Sun X, Wang M, Jiang Y, Ge QQ, Li T, et al. Meta‐analysis and machine learning reveal the antiobesity effects of melatonin on obese rodents. Obes. Rev. [Internet]. 2024[cited 2024 may 20];25(5):e13701. Available from: https://doi.org/10.1111/obr.13701.
Zhang R, Wang X, Ni L, Di X, Ma B, Niu S, et al. COVID-19: Melatonin as a potential adjuvant treatment. Life Sciences [Internet]. 2020 [cited 2024 may 20];250:117583. Available from: https://doi.org/10.1016/j.lfs.2020.117583.
Foley HM, Steel AE. Adverse events associated with oral administration of melatonin: A critical systematic review of clinical evidence. Complement. Ther. Med. [Internet]. 2019 [cited 2024 may 20];42:65–81. Available from: https://doi.org/10.1016/j.ctim.2018.11.003.
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