Melatonin as a treatment for patients with metabolic syndrome
DOI:
https://doi.org/10.9789/2175-5361.rpcfo.v17.14086Keywords:
MelatoninaAbstract
Objective: the study aimed to evaluate the use of melatonin as a treatment for patients with Metabolic Syndrome. Method: a systematic literature review was conducted, searching four databases for studies published from 2014 to 2024, following the PICO strategy and PRISMA statement recommendations. Randomized clinical trials were included, without language restrictions, evaluating melatonin intervention in patients with Metabolic Syndrome. Results: initially, 132 records were identified. After methodological evaluation, 3 articles were included in the review. The included studies addressed melatonin supplementation in patients with Metabolic Syndrome, showing promising results regarding oxidative stress markers and metabolic components. Some studies had limitations in the "Power," "External Validity," and "Reporting" domains of Downs and Black. Conclusion: melatonin demonstrated therapeutic potential in the treatment of Metabolic Syndrome with antioxidant effects and action on metabolic parameters.
Downloads
References
Alberti KGMM, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, et al. Harmonizing the Metabolic Syndrome: A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. [Internet]. 2009 [cited 2024 jun 05];120(16). Available from: https://doi.org/10.1161/circulationaha.109.192644.
Oliveira LVA, Santos BNSD, Machado ÍE, Malta DC, Velasquez-Melendez G, Felisbino-Mendes MS. Prevalence of the Metabolic Syndrome and its components in the Brazilian adult population. Ciên. Saúde Colet. [Internet]. 2020 [cited 2024 jun 05];25(11). Available from: https://doi.org/10.1590/1413-812320202511.31202020.
Liang M, Pan Y, Zhong T, Zeng Y, Cheng ASK. Effects of aerobic, resistance, and combined exercise on metabolic syndrome parameters and cardiovascular risk factors: a systematic review and network meta-analysis. Rev. Cardiovasc. Med. [Internet]. 2021 [cited 2024 jun 05];22(4). Available from: https://doi.org/10.31083/j.rcm2204156.
Di Cesare M, Perel P, Taylor S, Kabudula C, Bixby H, Gaziano TA, et al. The Heart of the World. Glob. Heart. [Internet]. 2024 2021 [cited 2024 jun 10];19(1). Available from: https://doi.org/10.5334/gh.1288.
Reiter RJ, Tan DX, Korkmaz A, Ma S. Obesity and metabolic syndrome: Association with chronodisruption, sleep deprivation, and melatonin suppression. Ann. Med. [Internet]. 2012 [cited 2024 jun 10];44(6). Available from: https://doi.org/10.3109/07853890.2011.586365.
Minich DM, Henning M, Darley C, Fahoum M, Schuler CB, Frame J. Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements. Nutrients. [Internet]. 2022 [cited 2024 jun 10];14(19). Available from: https://doi.org/10.3390/nu14193934.
Miola A, Fornaro M, Sambataro F, Solmi M. Melatonin and melatonin-agonists for metabolic syndrome components in patients treated with antipsychotics: A systematic review and meta-analysis. Hum. Psychopharmacol. [Internet]. 2022 [cited 2024 jun 10];37(2):e2821. Available from: https://doi.org/10.1002/hup.2821.
Guerra J, Devesa J. Melatonin Exerts Anti-Inflammatory, Antioxidant, and Neuromodulatory Effects That Could Potentially Be Useful in the Treatment of Vertigo. Int. J. Otolaryngol. [Internet]. 2021 [cited 2024 jun 15];2021:6641055. Available from: https://doi.org/10.1155/2021/6641055.
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. [Internet]. 2021 [cited 2024 jun 15];372(71). Available from: https://doi.org/10.1136/bmj.n71.
Sharma N, Srivastav AK, Samuel AJ. Ensaio clínico randomizado: padrão ouro de desenhos experimentais - importância, vantagens, desvantagens e preconceitos. Rev. Pesqui. Fisioter. [Internet]. 2020[acesso em 15 de junho 2024];10(3). Disponível em: https://doi.org/10.17267/2238-2704rpf.v10i3.3039.
Williams CYK, Townson AT, Kapur M, Ferreira AF, Nunn R, Galante J, et al. Interventions to reduce social isolation and loneliness during COVID-19 physical distancing measures: A rapid systematic review. PLoS One. [Internet]. 2021 [cited 2024 jun 15];16(2):e0247139. Available from: https://doi.org/10.1371/journal.pone.0247139.
PRISMA 2020 flow diagram. PRISMA statement. [Internet]. 2020 [cited 2024 jul 22]. Available from: https://www.prisma-statement.org/prisma-2020-flow-diagram.
Ghaderi-Zefrehi H, Seif F, Niayesh‐Mehr R, Ayashi S, Jafarirad S, Niknam Z, et al. Impact of the supplementation of melatonin on oxidative stress marker and serum endothelin-1 in patients with metabolic syndrome. Int. J. Diabetes Dev. Ctries. [Internet]. 2023 [cited 2024 may 12]; Available from: https://doi.org/10.1007/s13410-023-01266-5.
Abood SJ, Abdulsahib WK, Hussain SA, Ismail SH. Melatonin Potentiates the Therapeutic Effects of Metformin in Women with Metabolic Syndrome. Sci. Pharm. [Internet]. 2020 [cited 2024 may 12];88(2). Available from: https://doi.org/10.3390/scipharm88020028.
Goyal A, Terry PD, Superak HM, Nell-Dybdahl CL, Chowdhury R, Phillips LS, et al. Melatonin supplementation to treat the metabolic syndrome: a randomized controlled trial. Diabetol. Metab. Syndr. [Internet]. 2014 [cited 2024 may 12];6(1). Available from: https://doi.org/10.1186/1758-5996-6-124.
Hohor S, Mandanach C, Maftei A, Zugravu CA, Oțelea MR. Impaired Melatonin Secretion, Oxidative Stress and Metabolic Syndrome in Night Shift Work. Antioxidants. [Internet]. 2023 [cited 2024 may 12];12(4). Available from: https://doi.org/10.3390/antiox12040959.
Javid AZ, Hosseini SA, Gholinezhad H, Moradi L, Haghighi-zadeh MH, Bazyar H. Antioxidant and Anti-Inflammatory Properties of Melatonin in Patients with Type 2 Diabetes Mellitus with Periodontal Disease Under Non-Surgical Periodontal Therapy: A Double-Blind, Placebo-Controlled Trial. Diabetes Metab. Syndr. Obes. [Internet]. 2020 [cited 2024 may 12];13. Available from: https://doi.org/10.2147/dmso.s242208.
Esalatmanesh K, Loghman A, Esalatmanesh R, Soleimani Z, Khabbazi A, Mahdavi et al. Effects of melatonin supplementation on disease activity, oxidative stress, inflammatory, and metabolic parameters in patients with rheumatoid arthritis: a randomized double-blind placebo-controlled trial. Clin. Rheumatol. [Internet]. 2021 [cited 2024 may 12];40(9). Available from: https://doi.org/10.1007/s10067-021-05670-2.
Satari M, Bahmani F, Reiner Z, Soleimani A, Aghadavod E, Kheiripour N, et al. Metabolic and Anti-inflammatory Response to Melatonin Administration in Patients with Diabetic Nephropathy. Iran J. Kidney Dis. [Internet]. 2021 [cited 2024 may 12];1(1). Available from: https://ijkd.org/index.php/ijkd/article/view/5421/1240.
Ostadmohammadi V, Soleimani A, Bahmani F, Aghadavod E, Ramezani R, Reiter RJ, et al. The Effects of Melatonin Supplementation on Parameters of Mental Health, Glycemic Control, Markers of Cardiometabolic Risk, and Oxidative Stress in Diabetic Hemodialysis Patients: A Randomized, Double-Blind, Placebo-Controlled Trial. J. Ren. Nutr. [Internet]. 2020 [cited 2024 may 12];30(3). Available from: https://doi.org/10.1053/j.jrn.2019.08.003.
Overberg J, Kalveram L, Keller T, Krude H, Kühnen P, Wiegand S. Interactions between nocturnal melatonin secretion, metabolism, and sleeping behavior in adolescents with obesity. Int. J. Obes. [Internet]. 2022 [cited 2024 may 20];46(5). Available from: https://doi.org/10.1038/s41366-022-01077-4.
Genario R, Cipolla-Neto J, Bueno AA, Santos HO. Melatonin supplementation in the management of obesity and obesity-associated disorders: A review of physiological mechanisms and clinical applications. Pharmacol. Res. [Internet]. 2021 [cited 2024 may 20];163:105254. Available from: https://observatorio.fm.usp.br/handle/OPI/40015.
Peneva VM, Terzieva DD, Mitkov MD. Role of Melatonin in the Onset of Metabolic Syndrome in Women. Biomedicines. [Internet]. 2023 [cited 2024 may 20];11(6). Available from: https://doi.org/10.3390/biomedicines11061580.
Singhanat K, Apaijai N, Sumneang N, Maneechote C, Arunsak B, Chunchai T, et al. Therapeutic potential of a single-dose melatonin in the attenuation of cardiac ischemia/reperfusion injury in prediabetic obese rats. Cell. Mol. Life Sci. [Internet]. 2022 [cited 2024 may 20];79(6). Available from: https://doi.org/10.1007/s00018-022-04330-1.
Li Y, Sun X, Wang M, Jiang Y, Ge QQ, Li T, et al. Meta‐analysis and machine learning reveal the antiobesity effects of melatonin on obese rodents. Obes. Rev. [Internet]. 2024[cited 2024 may 20];25(5):e13701. Available from: https://doi.org/10.1111/obr.13701.
Zhang R, Wang X, Ni L, Di X, Ma B, Niu S, et al. COVID-19: Melatonin as a potential adjuvant treatment. Life Sciences [Internet]. 2020 [cited 2024 may 20];250:117583. Available from: https://doi.org/10.1016/j.lfs.2020.117583.
Foley HM, Steel AE. Adverse events associated with oral administration of melatonin: A critical systematic review of clinical evidence. Complement. Ther. Med. [Internet]. 2019 [cited 2024 may 20];42:65–81. Available from: https://doi.org/10.1016/j.ctim.2018.11.003.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Revista de Pesquisa Cuidado é Fundamental Online
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
TRANSFER AGREEMENT COPYRIGHT I transfer copyright of the article to the Journal of Care Survey is Fundamental - Online - RPCF, so it is accepted due to electronic publishing. The copyright includes the right to reproduce in whole or in part by any means, distributing that article, including figures, photographs, and any translations. The author can also print and distribute copies of your article, stating that since the rights belong to RPCF. I declare that this manuscript is original and has not been submitted for publication, in whole or in part to other online journals or not, so BMMC in the Annals of scientific events or book chapters.
