HIGH RATE OF DEPRESSION IN PATIENTS WITH CHRONIC HEPATITIS C
DOI:
https://doi.org/10.9789/2175-5361.rpcfo.v13.11384Keywords:
Chronic Hepatitis C, depression, DSM-V, hepatitis CAbstract
Objectives: To describe the frequency of depression in patients with hepatitis C (HCV) and relate to the biological variables and liver function.
Methods: Cross-sectional, descriptive study with a quantitative approach, which assessed depression using the criteria of the Diagnostic and Statistical Manual of Mental Disorders (DSM-V) and the association with biological and liver function variables in 85 patients HCV chronically infected indicated for direct-acting antiviral therapy (DAA) between May 2018 and May 2019.
Results: Depression was detected in 47.1% of patients, predominantly mild depression (95%). However, depression occurred independently of biological characteristics, such as gender, age, education, associated comorbidities and liver function, such as degree of fibrosis and viral genotype.
Conclusions: The frequency of depression was high in patients with HCV and had no statistical relationship with biological characteristics and liver function, suggesting that active search for depression could be a valuable strategy in managing these patients.
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REFERÊNCIAS
PCDT hepatites virais 2019. http://www.aids.gov.br/pt-br/pub/2017/protocolo-clinico-e-diretrizes-terapeuticas-para-hepatite-c-e-coinfeccoes. Accessed May 3, 2021.
Boletim Epidemiológico de Hepatites Virais 2020. http://www.aids.gov.br/pt-br/pub/2020/boletim-epidemiologico-hepatites-virais-2020. Accessed May 3, 2021.
Brasil. 342/2018 n. 13, de 13 de março, de 2018. Protocolo Clínico e Diretrizes Terapêuticas para Hepatite C e Coinfecções. http://www.aids.gov.br. Accessed May 3, 2021.
Mental Health Atlas 2017. Genebra: World Health Organization (WHO), 2017. https://apps.who.int/iris/bitstream/handle/10665/272735/9789241514019-eng.pdf. Accessed August 12, 2021.
Adinolfi LE, Nevola R, Rinaldi L, Romano C, Giordano M. Chronic Hepatitis C Virus Infection and Depression. Clinics in Liver Disease, 2017; 21(3):517-534. https://doi.org/10.1016/j.cld.2017.03.007.
Younossi ZM, Stepanova M, Henry L, Nader F, Younossi Y, Hunt S. Adherence to treatment of chronic hepatitis C: from interferon containing regimens to interferon and ribavirin free regimens. Medicine 2016; 95(28): e 4151.
Ho SB, Brau N, Cheung R, Liu L, Sanchez C, Sklar M, et al. Integrated care increases treatment and improves outcomes of patients with chronic hepatitis C virus infection and psychiatric illness or substance abuse. Clin Gastroenterol Hepatol 2015;13(11):2005-2014 (e1-3).
Egmond E, Mariño Z, Navines R, Oriolo G, Pla A, Bartres C, et al. Incidence of depression in patients with hepatitis C treated with direct-acting antivirals. Brazilian J Psychiatry. 2020;42(1):72–6.
Barreira DP, Marinho RT, Bicho M, Fialho R, Ouakinin SRS. Psychosocial and neurocognitive factors associated with hepatitis C - implications for future health and wellbeing. Front Psychol. 2019;9(JAN):1–6.
Fakoury MK, Pires MM, Ximenes CC V., Mello CEB. Frequência de Comprometimento Cognitivo em Pacientes com Hepatite C Crônica em um Hospital Universitário do Rio de Janeiro - Brasil. Cad Bras Med. 2020;1(4):60–5.
Yarlott L, Heald E, Forton D. Hepatitis C vírus infection, and neurological and psychiatric disorders – A review. J Adv Res. 2017 Mar, 8(2): 139-148. Published online 2016 Sep 19. doi: 10.1016/j.jare.2016.09.005
PMCID: PMC5272938
Abrantes, J.; Torres, D. S.; Mello, C. E. B. –. The Many Difficulties and Subtleties in the Cognitive Assessment of Chronic Hepatitis C Infection. International Journal Of Hepatology, Rio de Janeiro, v. 2020, p. 1-7, 19 mar. 2020. Hindawi Limited. http://dx.doi.org/10.1155/2020/9675235. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106929/. Accessed May 12, 2021.
Stanculete MF. Neurocognitive Impairments and Depression and Their Relationship to Hepatitis C Virus Infection. In: IntechOpen, editor. Liver Research and Clinical Management [Internet]. 2018. p. 203–18. DOI: 10.5772/intechopen.74054
Strahan, O. Viral Hepatitis C Associated Neurocognitive Dysfunction in Ireland in the Direct Acting Antiviral (DAA) Era, Trinity College Dublin.School of Psychology, 2020
American Psychiatric Association. DSM-5 - Manual diagnóstico e estatístico de transtornos mentais. 5ª. ed. Porto Alegre: Artmed; 2014.
Gascon, M. R. P.; et al. Cognitive assessment in patients with Hepatitis C submitted to treatment with Sofosbuvir and Simeprevir or Daclatasvir. Arquivos de Neuro-Psiquiatria, [S.L.], v. 78, n. 6, p. 342-348, jun. 2020.
Nunes, W.A.; et al. Cognição, funcionalidade e indicativo de depressão entre idosos. Rev. Rene. 2016 jan-fev; 17(1):103-11. Disponível em: http://www.periodicos.ufc.br/rene/article/view/2621/2008. Accessed August 12, 2021.
SOUTO, E P. Percepção da disponibilidade do capital social e sua associação com os transtornos mentais comuns e depressão: resultados do ELSA-Brasil. 2018. 103 f. Tese (Doutorado em Epidemiologia em Saúde Pública) - Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz, Rio de Janeiro, 2018.
Lopes CS, Hellwig N, Silva GA, Menezes PR. Inequities in access to depression treatment: results of the Brazilian National Health Survey - PNS. Int J Equity Health 2016; 15:154.
WHO. Hepatitis C [Internet]. WHO. 2020 [cited 2021 Apr 7]. Available from: https://www.who.int/news-room/fact-sheets/detail/hepatitis-c. Accessed August 12, 2021.
World Health Organization (WHO. Guidelines for the screening, care and treatment of persons with chronic hepatitis C infection. Updated version. Geneva: WHO, 2016. Accessed August 12, 2021.
IBGE, Brasil: Pesquisa nacional de saúde: 2019; informações sobre domicílios, acesso e utilização dos serviços de saúde: Brasil, grandes regiões e unidades da federação / IBGE, Coordenação de Trabalho e Rendimento. - Rio de Janeiro: IBGE, 2020. Disponível em: https://biblioteca.ibge.gov.br/visualizacao/livros/liv101748.pdf. Acesso em 02/09/2021
European Association for the Study of the Liver. EASL recommendations on treatment of hepatitis C 2018. J Hepatol Apr 9, 2018.
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