Transfusion complications in hospitalized elderly patients: integrative literature review
DOI:
https://doi.org/10.9789/2175-5361.rpcfo.v15.12175Keywords:
Blood transfusion; Transfusion reaction; Aged; Hospitals.Abstract
Objective: to identify studies on the main complications that blood transfusion can cause to the health of hospitalized elderly and to analyze the scientific evidence found. Method: integrative review carried out with studies in English from national and international databases published from 2017 to 2021. The main descriptors were “Blood Transfusion”, “Transfusion Reaction”, “Aged” and “Hospitalization”, combined through of the Boolean operators “AND” and “OR”. Results: 23 studies were included that portrayed the main complications of blood transfusion for the hospitalized elderly person. The twelve different complications were allocated into two categories: surgery-related or non-surgical complications. Longer hospital stay, mortality, transfusion reactions, postoperative acute kidney injury and postoperative delirium were part of the main findings. Conclusion: the mechanisms by which complications develop are not yet fully understood, highlighting the importance of encouraging new research involving this topic.
DESCRIPTORS: Blood transfusion; Transfusion reaction; Aged; Hospitals.
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Almeida APSC, Nunes BP, Duro SMS, Lima RCD, Facchini LA. Lack of access and the trajectory of healthcare use by elderly Brazilians. Ciênc. saúde coletiva. [Internet]. 2020 [cited 2022 nov 20];25(6). Available from: https://doi.org/10.1590/1413-81232020256.27792018
Sousa NDS, Menezes TN, Silva NA, Eulálio MC, Paiva AA. Prevalência de anemia e correlação da concentração de hemoglobina com fatores cognitivos em idosos. Ciênc. saúde coletiva. [Internet]. 2018 [acesso em 22 de novembro 2022];23(3). Disponível em: https://doi.org/10.1590/1413-81232018233.09082016
Arruda ABL, Monteiro SG, Arruda AAL, Gondim YM, Lima AIH. Caracterização da anemia em idosos. Braz. J. Hea. Rev. [Internet]. 2019 [acesso em 20 de novembro 2022];2(5). Disponível em:
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/4140
De Santis GC. Anemia: definição, epidemiologia, fisiopatologia, classificação e tratamento. Medicina. [Internet]. 2019 [acesso em 02 de dezembro 2022];52(3). Disponível em: https://www.revistas.usp.br/rmrp/article/view/156726
Bolcato M, Russo M, Trentino K, Isbister J, Rodriguez D, Aprile A. Patient blood management: The best approach to transfusion medicine risk management. Transfus Apher Sci. [Internet]. 2020 [cited 2023 feb 27];59(4). Available from: https://doi.org/10.1016/j.transci.2020.102779
Ackfeld T, Schmutz T, Guechi Y, Le Terrier C. Blood Transfusion Reactions — A Comprehensive Review of the Literature including a Swiss Perspective. J. Clin Med. [Internet]. 2022 [cited 2023 feb 27];11(10). Available from: https://doi.org/10.3390/jcm11102859. DOI: 10.3390/jcm11102859
Sanguineo GZ, Previato GF, Silva AF, Meireles VC, Góes HLF, Baldissera VDA. O trabalho de enfermagem no cuidado ao idoso hospitalizado: limites e particularidades. Rev Fund Care Online. [Internet]. 2018 [acesso em 05 de dezembro 2022]; 10(1). Disponível em: https://doi.org/10.9789/2175-5361.2018.v10i1.160-166.
Zhao H, You J, Peng Y, Feng Y. Machine Learning Algorithm Using Electronic Chart-Derived Data to Predict Delirium After Elderly Hip Fracture Surgeries: A Retrospective Case-Control Study. Front Surg. [Internet]. 2021 [cited 2023 jan 08];13(8). Available from: https://pubmed.ncbi.nlm.nih.gov/34327210/
Vieira CM de AS, Santos KB. O conhecimento da equipe de enfermagem em transfusão de hemocomponentes: uma revisão integrativa. Rev Fund Care Online. [Internet]. 2021 [acesso em 15 de agosto 2022];12. Disponível em: https://doi.org/10.9789/2175-5361.rpcfo.v12.8623
Frantz SRS, Vargas MAO. Renormalização do trabalho do enfermeiro em hemoterapia: entre o prescrito e o real. Texto contexto – enferm. [Internet]. 2021 [acesso em 05 de dezembro 2022];30:e20190060. Disponível em: https://doi. org/10.1590/1980-265X-TCE-2019-0060
Paiva MRF, Parente JRF, Brandão IR, Queiroz AHB. Metodologias Ativas de ensino-aprendizagem: Revisão Integrativa. SANARE - Rev. Políticas Públicas. [Internet]. 2017 [acesso em 17 de junho 2022];15(2). Disponível em: https://sanare.emnuvens.com.br/sanare/article/view/1049
Mendes KDS, Silveira RCCP, Galvão CM. Uso de gerenciador de referências bibliográficas na seleção dos estudos primários em revisão integrativa. Texto contexto – enferm. [Internet]. 2019 [acesso em 22 de agosto 2022];28:e20170204. Disponível em: https://doi.org/10.1590/1980-265X-TCE-2017-0204
Institute TJB. Joanna Briggs Institute Reviewers' Manual: 2011 Edition. [Internet]. Adelaide: Joanna Briggs Institute; 2011. [cited jul 21 2021]. Available from: http://joannabriggs.org/assets/docs/sumari/ReviewersManual-2014.pdf
Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) 2015 statement. Syst Rev. [Internet]. 2015 [cited 2022 aug 15];4(1). Available from: https://systematicreviewsjournal.biomedcentral.com/articles/10.1186/2046-4053-4-1
Leite RCN, Sousa WCM, Lima KA, Silva SPC. Transfusion complications in hospitalized elderly patients: Protocol of an Integrative Review of Scientific Literature. Figshare. 2022 [cited 2022 sep 05]. Available from: https://doi.org/10.6084/m9.figshare.19658838.v8
Melnyk BM, Fineout-Overholt E. Evidence-based practice in nursing & healthcare: a guide to best practice. Philadelphia: Lippincott Williams & Wilkins; 2005.
Karafin MS, Bruhn R, Westlake M, Sullivan MT, Bialkowski W, Edgren G, et al. Demographic and epidemiologic characterization of transfusion recipients from four US regions: evidence from the REDS-III recipient database. Transfusion. [Internet]. 2017 [cited 2022 jun 06];57(2). Available from: https://doi.org/10.1111/trf.14370
Lo CK, Lee QJ, Wong YC. Predictive factors for length of hospital stay following primary total knee replacement in a total joint replacement centre in Hong Kong. Hong Kong Med Journal. [Internet]. 2017 [cited 2022 jun 22];23(5). Available from: https://doi.org/10.12809/hkmj166113
Van der Sluis FJ, Buisman PL, Meerdink M, Aan de Stegge WB, Van Etten B, Bock GH, et al. Risk factors for postoperative delirium after colorectal operation. Surgery. [Internet]. 2017 [cited 2022 jun 20];161(3). Available from: https://doi.org/10.1016/j.surg.2016.09.010
Campos IC, Tanganelli V, Maues HP, Coelho MCM, Martins FA, Munhoz G, et al. Blood transfusion and increased perioperative risk in coronary artery bypass grafts. Braz. J. Cardiovasc. Surgery. [Internet]. 2017 [cited 2022 jun 27]; 32(5). Available from: https://doi.org/10.21470/1678-9741-2017-0034
Yamada C, Iwawaki Y, Harada K, Fukui M, Morimoto M, Yamanaka R. Frequency and risk factors for subsyndromal delirium in an intensive care unit. Intensive Crit Care Nursing [Internet]. 2018 [cited 2022 jun 22];47. Available from: https://doi.org/10.1016/j.iccn.2018.02.010
Leuzinger E, Poblete B, Konrad CJ, Hansen D. How current transfusion practices in geriatric patients with hip fracture still differ from current guidelines and the effects on outcome: A retrospective observational study. Eur J Anaesthesiology. [Internet]. 2018 [cited 2022 jun 26];35(12). Available from: https://doi.org/10.1097/EJA.0000000000000883
Kindzelski BA, Corcoran P, Siegenthaler MP, Horvath KA. Postoperative acute kidney injury following intraoperative blood product transfusions during cardiac surgery. Perfusion. [Internet]. 2018 [cited 2022 jun 26];33(1). Available from: https://doi.org/10.1177/0267659117712405
Kang W, Wu X. Pre-, Intra-, and Post-Operative Factors for Kidney Injury of Patients Underwent Cardiac Surgery: A Retrospective Cohort Study. Med Science Monitor. [Internet]. 2019 [cited 2022 jun 26];25. Available from: https://doi.org/10.12659/MSM.915996
Chou MY, Wang YC, Peng LN, Liang CK, Chu CS, Liao MC, et al. Intraoperative blood transfusion predicts postoperative delirium among older patients undergoing elective orthopedic surgery: A prospective cohort study. Int J Geriatr Psychiatry. [Internet]. 2019 [cited 2022 jun 26];34(6). Available from: https://doi.org/10.1002/gps.5086
Huang J, Sprung J, Weingarten TN. Delirium following total joint replacement surgery. Bosn J Basic Med Science. [Internet]. 2019 [cited 2022 jun 30];19(1). Available from: https://doi.org/10.17305/bjbms.2018.3653
Chamoun K, Kantarjian HM, Wang X, Naqvi K, Aung F, Garcia-Manero G, et al. Unrecognized fluid overload during induction therapy increases morbidity in patients with acute promyelocytic leukemia. Cancer. [Internet]. 2019 [cited 2022 jun 30];125(18). Available from: https://doi.org/10.1002/cncr.32196
Zeng Q, Tan S, Bao Q, Jiang S. Intra-operative blood transfusion significantly increases the risk of post-operative pulmonary embolism. J Thorac Disease. [Internet]. 2019 [cited 2022 jun 23];11(12). Available from: https://doi.org/10.21037/jtd.2019.11.10
Akbaş T. Long length of stay in the ICU associates with a high erythrocyte transfusion rate in critically ill patients. J Int Med Research. [Internet]. 2019 [cited 2022 jun 23]; 47(5). Available from: https://doi.org/10.1177/0300060519832458
Jang SY, Cha YH, Yoo JI, Oh T, Kim JT, Park CH, et al. Blood Transfusion for Elderly Patients with Hip Fracture: a Nationwide Cohort Study. J Korean Med Science. [Internet]. 2020 [cited 2022 jun 30];35(37). Available from: https://doi.org/10.3346/jkms.2020.35.e313
Politou M, Valsami S, Dryllis G, Chistodoulaki M, Cheropoulu C, Pouliakis A, et al. Retrospective Study on Prevalence, Specificity, Sex, and Age Distribution of Alloimmunization in Two General Hospitals in Athens. Turk J Haematol. [Internet]. 2020 [cited 2022 jul 01];37(3). Available from: https://doi.org/10.4274/tjh.galenos.2020.2019.0459
Christensen JB, Aasbrenn M, Castillo LS, Ekmann A, Jensen TG, et al. Predictors of Acute Kidney Injury After Hip Fracture in Older Adults. Geriatr Orthop Surg Rehabil. [Internet]. 2020 [cited 2022 jul 01];11:2151459320920088. Available from: https://doi.org/10.1177/2151459320920088
Küpeli İ, Ünver S. The Correlation between Preoperative and Postoperative Hypoalbuminaemia and the Development of Acute Kidney Injury with Respect to the KDIGO Criteria in the Hip Fracture Surgery in Elderly Patients. Turk J Anaesthesiol Reanim. [Internet]. 2020 [cited 2022 jul 01];48(1). Available from: https://doi.org/10.5152/TJAR.2019.65642
Crawford JE, Zubair F, Baniulyte G, Wales CJ, Ansell M, Thomson E, et al. Postoperative delirium in patients with head and neck oral cancer in the West of Scotland. Br J Oral Maxillofac Surgery. [Internet]. 2021 [cited 2022 jul 01]; 59(3). Available from: https://doi.org/10.1016/j.bjoms.2020.08.116
Yin Y, Tian X, Li L, Kong Y, Wang J, Lin F, et al. Chinese Haemovigilance Network: first annual report of Chinese haemovigilance network. Vox Sang. [Internet]. 2021 [cited 2022 jul 01]; 116(6). Available from: https://doi.org/10.1111/vox.13059
Miniksar HÖ, Ozdemir M. Clinical Features and Outcomes of Very Elderly Patients Admitted to the Intensive Care Unit: A Retrospective and Observational Study. Indian J Crit Care Med. [Internet]. 2021 [cited 2022 jul 05]; 25(6). Available from: https://doi.org/10.5005/jp-journals-10071-23846
Fuller CC, Nambudiri VE, Spencer-Smith C, Curtis LH, Shinde M, Cosgrove A, et al. Medical chart validation of inpatient diagnosis codes for transfusion-related acute lung injury 2013-2015. Transfusion. [Internet]. 2021 [cited 2022 jul 05];61(3). Available from: https://doi.org/10.1111/trf.16251
Devani K, Radadiya D, Charilaou P, Aasen T, Reddy CM, Young M, et al. Trends in hospitalization, mortality, and timing of colonoscopy in patients with acute lower gastrointestinal bleeding. Endosc Int Open. [Internet]. 2021 [cited 2022 jul 05];9(6). Available from: https://doi.org/10.1055/a-1352-3204
Arshi A, Lai WC, Iglesias BC, McPherson EJ, Zeegen EN, Stavrakis AI, et al. Blood transfusion rates and predictors following geriatric hip fracture surgery. Hip Int. [Internet]. 2021 [cited 2022 jul 05];31(2). Available from: https://doi.org/10.1177/1120700019897878
Roubinian N. TACO and TRALI: biology, risk factors, and prevention strategies. Hematology Am Soc Hematol Educ Program. [Internet]. 2018 [cited 2022 jul 05];(1). Available from: https://pubmed.ncbi.nlm.nih.gov/30570487/
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