Events supposedly attributable to vaccination or immunization against Covid-19 in Brazil – scoping review
DOI:
https://doi.org/10.9789/2175-5361.rpcfo.v17.13412Keywords:
Injection site raction, Adults, Elderly, Vaccine against covid-19Abstract
Objective: to identify in the scientific literature the types of events supposedly attributable and their factors associated with and related to vaccination against Covid-19 in adults and elderly people in Brazil. Method: scoping review, carried out from June to August 2023; Primary studies were selected, available in full, published from January 2021 to August 2023, in Portuguese, English or Spanish, in the following databases: Embase, Pubmed, Scopus and VHL. Results: 14 articles made up the final sample; It was demonstrated that the occurrence of events supposedly attributable to vaccination or immunization is frequent, mostly non-serious adverse events, however, serious adverse events have also been reported, such as thrombosis of the central nervous system, convulsions, dyspnea, facial paralysis and deaths. Conclusions: The predominance of cases reported in the studies were related to the Oxford-AstraZeneca vaccine and occurred mainly in women, aged 30 to 50 years.
Downloads
References
Lana RM, Coelho FC, Gomes MF da C, Cruz OG, Bastos LS, Villela DAM, et al.. Emergência do novo coronavírus (SARS-CoV-2) e o papel de uma vigilância nacional em saúde oportuna e efetiva. Cad Saúde Pública [Internet]. 2020;36(3):e00019620. Disponível em: https://doi.org/10.1590/0102-311X00019620
Souza WV de, Martelli CMT, Silva AP de SC, Maia LT de S, Braga MC, Bezerra LCA, et al.. Cem dias de COVID-19 em Pernambuco, Brasil: a epidemiologia em contexto histórico. Cad Saúde Pública [Internet]. 2020;36(11):e00228220. Disponível em: https://doi.org/10.1590/0102-311X00228220
Galhardi CP, Freire NP, Fagundes MCM, Minayo MC de S, Cunha ICKO. Fake news e hesitação vacinal no contexto da pandemia da COVID-19 no Brasil. Ciênc saúde coletiva [Internet]. 2022May;27(5):1849–58. Disponível em: https://doi.org/10.1590/1413-81232022275.24092021
Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Protocolo de vigilância epidemiológica de eventos adversos pós-vacinação. Estratégia de vacinação contra o vírus SARS-CoV-2 (COVID-19) [Internet]. Brasília: Ministério da Saúde; 2020. Disponível em: https://pesquisa.bvsalud.org/portal/resource/pt/biblio-1247801
Bisetto LHL, Cubas MR, Malucelli A. A prática da enfermagem frente aos eventos adversos pós-vacinação. Rev esc enferm USP [Internet]. 2011 Oct;45(5):1128–34. Disponível em: https://doi.org/10.1590/S0080-62342011000500014
Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Vigilância em Saúde: volume 3. 6ª ed. Brasília: Ministério da Saúde; 2023. Disponível em: https://www.gov.br/saude/pt-br/centrais-de-conteudo/publicacoes/svsa/vigilancia/guia-de-vigilancia-em-saude-volume-3-6a-edicao/view.
Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Nota Técnica nº 255/2022 CGPNI/DEIDT/SVS/MS. Brasília: Ministério da Saúde; 2022. Disponível em: https://www.gov.br/saude/pt-br/vacinacao/esavi/notas-tecnicas/nt-255-2022-cgpni-deidt-svs-ms.pdf/view.
Peters MDJ, Godfrey C, McInerney P, Munn Z, Tricco AC, Khalil, H. Chapter 11: Scoping Reviews (2020 version). In: Aromataris E, Munn Z (Editors). , JBI, 2020. Disponível em: JBI Manual for Evidence Synthesis from . https://synthesismanual.jbi.global https://doi.org/10.46658/JBIMES-20-12
Tricco AC, Lillie E, Zarin W, O’Brien KK, Colquhoun H, Levac D, et al. PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation. Annals of Internal Medicine. 2018 Sep 4;169(7):467–73. Disponível em: https://doi.org/10.7326/M18-0850
Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA Statement. PLoS Medicine. 2009 Jul 21;6(7). Disponível em: https://doi.org/10.1371/journal.pmed.1000097
Cantarelli Rodrigues T, Hidalgo PF, Skaf AY, Serfaty A. Subacromial-subdeltoid bursitis following COVID-19 vaccination: a case of shoulder injury related to vaccine administration (SIRVA). Skeletal Radiology. 2021 May 4; Disponível em: https://doi.org/10.1007/s00256-021-03803-x
Viana JA, Fonseca EKUN, Sawamura MVY. Post COVID-19 vaccine adenopathy: first Brazilian report. J bras pneumol [Internet]. 2021;47(4):e20210206. Disponível em: https://doi.org/10.36416/1806-3756/e20210206
Silva RB da, Silva TPR da, Sato APS, Lana FCF, Gusmão JD, Souza JFA, et al.. Adverse events following immunization against SARS-CoV-2 (covid-19) in the state of Minas Gerais. Rev Saúde Pública [Internet]. 2021;55:66. Disponível em: https://doi.org/10.11606/s1518-8787.2021055003734
Mouta Nunes de Oliveira P, Mendes-de-Almeida DP, Bertollo Gomes Porto V, Crespo Cordeiro C, Vitiello Teixeira G, Saraiva Pedro R, et al. Vaccine-induced immune thrombotic thrombocytopenia after COVID-19 vaccination: Description of a series of 39 cases in Brazil. Vaccine [Internet]. 2022 Aug 5;40(33):4788–95. Disponível em: https://doi.org/10.1016/j.vaccine.2022.06.014
Martins-Filho PR, Santana RRR, Cavalcante TF, Barboza W de S, de Souza MF, Góes MA de O, et al. Surveillance of adverse events associated with 145 000 doses of COVID-19 vaccines in a Brazilian municipality. Revista Panamericana De Salud Publica = Pan American Journal of Public Health [Internet]. 2022 [cited 2024 May 14];46:e110. Disponível em: https://doi.org/10.26633/RPSP.2022.110
Tavares-Júnior JWL, Coimbra PP de A, Braga-Neto P. Post Coronavirus Disease 2019 Vaccine-associated Acute Myeloradiculoneuropathy Responsive to Plasmapheresis. Revista Da Sociedade Brasileira De Medicina Tropical [Internet]. 2022;55:e0015. Disponível em: https://doi.org/10.1590/0037-8682-0015-2022
Ballestero M, Souza RLP de, Sakae TM, Costa LGV da, Furlanetti L, Oliveira RS de. Post-vaccination incidence and side effects of COVID-19 in a cohort of Brazilian healthcare professionals: an internet-based survey. Einstein (São Paulo) [Internet]. 2022;20:eAO0067. Disponível em: https://doi.org/10.31744/einstein_journal/2022AO0067
Fritzen M, Di G, Luiz MO, Durigon GS. Vasculite leucocitoclástica após exposição à vacina para COVID‐19. Anais Brasileiros de Dermatologia (Portuguese) [Internet]. 2022 [cited 2024 May 11];97(1):118–21. Disponível em: https://doi.org/10.1016/j.abdp.2021.09.029
Ortigosa LCM, Lenzoni FC, Suárez MV, Duarte AA, Prestes-Carneiro LE. Hypersensitivity reaction to hyaluronic acid dermal filler after COVID-19 vaccination: A series of cases in São Paulo, Brazil. International Journal of Infectious Diseases. 2022 Mar;116:268–70. Disponível em: https://doi.org/10.1016/j.ijid.2022.01.024
Zamoner W, Scardini JB, De Dio BJ, Marques A de M, Silva VDS, Garcia AL, et al. ANCA-associated vasculitis following Oxford-AstraZeneca COVID-19 vaccine in Brazil: Is there a causal relationship? A case report. Frontiers in Medicine [Internet]. 2022 [cited 2024 May 14];9:1003332. Disponível em: https://doi.org/10.3389/fmed.2022.1003332
Eyer-Silva W de A, Leme LS de CP. Facial Angioedema after the first dose of Covishield (adenovirus-vectored severe acute respiratory syndrome coronavirus 2 vaccine): follow-up after the second and third booster doses. Rev Soc Bras Med Trop [Internet]. 2022;55:e0063–2022. Disponível em: https://doi.org/10.1590/0037-8682-0063-2022
Tomishige KS, Novais EA, Finamor LP dos S, Nascimento HM do, Belfort Jr. R. Multiple evanescent white dot syndrome (MEWDS) following inactivated COVID-19 vaccination (Sinovac-CoronaVac). Arq Bras Oftalmol [Internet]. 2022Mar;85(2):186–9. Disponível em: https://doi.org/10.5935/0004-2749.20220070
Ann S, Magno C, Crowe M, Pollard A, Karen Ingrid Tasca, Tommasini M, et al. Safety of the Fiocruz ChAdOx COVID-19 vaccine used in a mass vaccination campaign in Botucatu, Brazil. Vaccine. 2022 Nov 1;40(47):6722–9. Disponível em: doi https://doi.org/10.1016/j.vaccine.2022.08.026
Tavares-Júnior JWL, Sobreira-Neto MA, Braga-Neto P. Cogan’s sign in a patient with suspected post-COVID-19 vaccine-associated myasthenia gravis. Rev Soc Bras Med Trop [Internet]. 2023;56:e0007–2023. Disponível em: https://doi.org/10.1590/0037-8682-0007-2023
Downloads
Published
Versions
- 2025-03-28 (3)
- 2025-03-18 (2)
- 2025-02-20 (1)
How to Cite
Issue
Section
License
Copyright (c) 2025 Revista de Pesquisa Cuidado é Fundamental Online

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
TRANSFER AGREEMENT COPYRIGHT I transfer copyright of the article to the Journal of Care Survey is Fundamental - Online - RPCF, so it is accepted due to electronic publishing. The copyright includes the right to reproduce in whole or in part by any means, distributing that article, including figures, photographs, and any translations. The author can also print and distribute copies of your article, stating that since the rights belong to RPCF. I declare that this manuscript is original and has not been submitted for publication, in whole or in part to other online journals or not, so BMMC in the Annals of scientific events or book chapters.