Therapeutic benefits of cannabinoids in the treatment of chronic pain in cancer patients / Benefícios Terapêuticos dos Canabinoides no Tratamento da Dor Crônica em Pacientes com Câncer
DOI:
https://doi.org/10.9789/2175-5361.rpcfo.v14.11627Palavras-chave:
Cannabis, Cannabis sativa, Maconha Medicinal, Dor crônica, Dor do câncerResumo
Objetivo: apresentar o estado da arte das publicações expressas na literatura cientifica mundial sobre a temática, bem como identificar os benefícios terapêuticos da Cannabis medicinal no tratamento da dor. Método: trata-se de uma revisão integrativa da literatura, cuja busca de dados foi realizada nas bibliotecas virtuais. Web of Science, Scopus, Medline, IBECS, Lilacs, Cochrane Library, Emerald Insight e Scielo no período de agosto a outubro de 2021. Resultados: foram encontrados 367 artigos. Quarenta e três artigos foram selecionados para serem lidos na íntegra e 15 atenderam aos critérios desta revisão. Conclusão: as evidências mostram que embora cada vez mais prescritos ou autorizados, a cannabis medicinal ou os Canabinóides para a dor crónica continuam a ser controversos para muitos médicos.
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Silva RR da, Silva LA da. Psychosocial load and burnout syndrome in healthcare professionals in the fight against COVID-19 pandemic. Rev. Pesqui. (Univ. Fed. Estado Rio J., Online). [Internet]. 2021 [cited 2021 nov 18]; 13. Available from: https://doi.org/10.9789/2175-5361.rpcfo.v13.11097.
Silva RR da, Neves MP das, Silva LA da, Silva MVG, Hipolito RL, Marta CB. Consumo de drogas psicoativas em contexto de sexual entre homens gays como fator de risco para transmissão de HIV/Aids. Glob Acad Nurs. [Internet]. 2020 [acesso em 18 de novembro 2021]; 1(3). Disponível em: https://doi.org/10.5935/2675-5602.20200057.
Silva RR da, Silva LA da, Souza MVL de, Silva MVG da, Neves MP das, Vargas D, et al. Minority gender stress and its effects on mental health as a risk factor for depression in transgender persons: Literature review. Res Soc Dev. [Internet]. 2021 [cited 2021 nov 18]; 10(12): e51610313693. Available from: https://doi.org/10.33448/rsd-v10i3.13693.
Orjuela-Rojas JM, Orjuela XG, Serna SO. Medicinal cannabis: knowledge, beliefs, and attitudes of colombian psychiatrists. J cannabis Res. 2021 [cited 2021 nov 18]; 3(1). Available from: https://doi.org/10.1186/s42238-021-00083-z.
Silva IN de CJAG da. Estimativa 2020: incidência de câncer no Brasil TT - estimate/2020 ¬ cancer incidence in Brazil TT. [Internet]. 2020. p. 120. Disponível em: https://www.inca.gov.br/sites/ufu.sti.inca.local/files//media/document//estimativa-2020-incidencia-de-cancer-no-brasil.pdf.
Fowler CJ. The endocannabinoid system - current implications for drug development. J. intern. med. [Internet]. 2021 [cited 2021 nov 18]; 290(1). Available from: https://dx.doi.org/10.1111/joim.13229.
Boland EG, Bennett MI, Allgar V, Boland JW. Cannabinoids for adult cancer-related pain: systematic review and meta-analysis. BMJ support. palliat. care (Online). [Internet]. 2020 [cited 2021 nov 18]; 10(1). Available from: http://dx.doi.org/10.1136/bmjspcare-2019-002032.
Kaufmann CN, Kim A, Miyoshi M, Han BH. Patterns of medical cannabis use among older adults from a cannabis dispensary in New York State. Cannabis Cannabinoid Res. [Internet]. 2020 [cited 2021 nov 18]; 0(0). Available from: http://doi.org/10.1089/can.2020.0064.
Chapman EJ, Edwards Z, Boland JW, Maddocks M, Fettes L, Malia C, et al. Practice review: evidence-based and effective management of pain in patients with advanced cancer. Palliat. med. [Internet]. 2020 [cited 2021 nov 18]; 34(4). Available from: https://doi.org/10.1177/0269216319896955.
Daris B, Verboten MT, Knez Z, Ferk P. Cannabinoids in cancer treatment: Therapeutic potential and legislation. Bosn. j. basic med. sci. (Print). [Internet]. 2019 [cited 2021 nov 18]; 19(1). Available from: https://doi.org/10.17305/bjbms.2018.3532.
Tran T, Kavuluru R. Social media surveillance for perceived therapeutic effects of cannabidiol (CBD) products. Int. j. drug policy. [Internet]. 2020 [cited 2021 nov 18]; 77. Available from: https://doi.org/10.1016/j.drugpo.2020.102688.
Lowe H, Toyang N, Steele B, Bryant J, Ngwa W, Nedamat K. The current and potential application of medicinal cannabis products in dentistry. Dent. j. [Internet]. 2021 [cited 2021 nov 18]; 9(9). Available from: https://doi.org/10.3390/dj9090106.
Fehniger J, Brodsky AL, Kim A, Pothuri B. Medical marijuana utilization in gynecologic cancer patients. Gynecol. Oncol. Rep. [Internet]. 2021 [cited 2021 nov 18]; 37. Available from: https://doi.org/10.1016/j.gore.2021.100820.
Argueta DA, Ventura CM, Kiven S, Sagi V, Gupta K. A balanced approach for cannabidiol use in chronic pain. Front. pharmacol. [Internet]. 2020 [cited 2021 nov 18]; 11. Available from: https://doi.org/10.3389/fphar.2020.00561.
Moher D. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. Ann. intern. med. [Internet]. 2009 [cited 2021 nov 18]; 151(4). Available from: https://doi.org/10.7326/0003-4819-151-4-200908180-00135.
Granholm A, Alhazzani W, Møller MH. Use of the GRADE approach in systematic reviews and guidelines. Br. j. anaesth. [Internet]. 2019 [cited 2021 nov 18]; 123(5). Available from: https://doi.org/10.1016/j.bja.2019.08.015.
Dzierzanowski T. Prospects for the use of cannabinoids in oncology and palliative care practice: a review of the evidence. Cancers. [Internet]. 2019 [cited 2021 nov 18]; 11(2). Available from: https://doi.org/10.3390/cancers11020129.
Bolshakova M, Bluthenthal R, Sussman S. Opioid use and misuse: health impact, prevalence, correlates and interventions. Psychol. health. [Internet]. 2019 [cited 2021 nov 18]; 34(9). Available from: https://doi.org/10.1080/08870446.2019.1622013.
Noori A, Miroshnychenko A, Shergill Y, Atefeh N, Miroshnychenko A, Shergill Y, et al. Opioid-sparing effects of medical cannabis or cannabinoids for chronic pain: a systematic review and meta-analysis of randomised and observational studies. BMJ Open. [Internet]. 2021 [cited 2021 nov 18]; 11: e047717. Available from: https://doi.org/10.1136/bmjopen-2020-047717.
Amato L, Minozzi S, Mitrova Z, Parmelli E, Saulle R, Cruciani F, et al. Systematic review of safeness and therapeutic efficacy of cannabis in patients with multiple sclerosis, neuropathic pain, and in oncological patients treated with chemotherapy. Epidemiol. prev. [Internet]. 2017 [cited 2021 nov 18]; 41 (5-6). Available from: https://doi.org/10.19191/EP17.5-6.AD01.069.
Ananth P, Ma C, Al-Sayegh H, Kroon L, Klein V, Wharton C, et al. Provider perspectives on use of medical marijuana in children with cancer. Pediatrics [Internet]. 2018 [cited 2021 nov 18]; 141(1): e20170559. Available from: https://doi.org/10.1542/peds.2017-0559.
Braun IM, Wright A, Peteet J, Meyer FL, Yuppa DP, Bolcic-Jankovic D, et al. Medical oncologists' beliefs, practices, and knowledge regarding marijuana used therapeutically: a nationally representative survey study. J. clin. oncol. [Internet]. 2018 [cited 2021 nov 18]; 36(19). Available from: https://doi.org/10.1200/JCO.2017.76.1221.
Kim A, Kaufmann CN, Ko R, Li Z, Han BH. Patterns of medical cannabis use among cancer patients from a medical cannabis dispensary in New York State. J. palliat. med. [Internet]. 2019 [cited 2021 nov 18]; 22(10). Available from: https://doi.org/10.1089/jpm.2018.0529.
Good P, Haywood A, Gogna G, Martin J, Yates P, Greer R, et al. Oral medicinal cannabinoids to relieve symptom burden in the palliative care of patients with advanced cancer: a double-blind, placebo controlled, randomised clinical trial of efficacy and safety of cannabidiol (CBD). BMC palliat. care. [Internet]. 2019 [cited 2021 nov 18]; 18(1). Available from: https://dx.doi.org/10.1186/s12904-019-0494-6.
Lee C, Round JM, Klarenbach S, Hanlon JG, Hyshka E, Dyck JRB, et al. Gaps in evidence for the use of medically authorized cannabis: Ontario and Alberta, Canada. Harm reduct. j. [Internet]. 2021 [cited 2021 nov 18]; 18(1). Available from: https://doi.org/10.1186/s12954-021-00509-0.
Noori A, Busse JW, Sadeghirad B, Siemieniuk RA, Wang L, Couban R, et al. Individual opioids, and long-versus short-acting opioids, for chronic noncancer pain Protocol for a network meta-analysis of randomized controlled trials. Medicine (Baltimore). [Internet]. 2019 [cited 2021 nov 18]; 98(43). Available from: http://dx.doi.org/10.1097/MD.0000000000017647.
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