THE  EFFECT OF HERBAL APPROACHES ON ORAL MUCOSITIS IN ADULT CANCER PATIENTS - A SYSTEMATIC REVIEW OF NURSING STUDIES

Fatma Özkan Tuncay; Sena Nur Yapar

doi:10.9789/2175-5361.rpcfo.v16.13234

Autores

Fatma Özkan Tuncay Sivas Cumhuriyet Üniversitesi https://orcid.org/0000-0001-8059-1821
Sena Nur Yapar Sivas Cumhuriyet Üniversitesi https://orcid.org/0000-0003-4068-901X

DOI:

https://doi.org/10.9789/2175-5361.rpcfo.v16.13234

Palavras-chave:

Intervenções herbais, Mucosite, Revisão sistemática

Resumo

Objetivo: examinar os efeitos das abordagens herbais na mucosite oral em pacientes adultos com câncer. Método: revisão sistemática seguindo as diretrizes da Cochrane, com uma busca por estudos experimentais e randomizados entre 2013 e 2023. Foram incluídos estudos em inglês sobre intervenções herbais em pacientes com mais de 18 anos. Resultados: foram avaliados oito estudos que usaram intervenções herbais para tratar a mucosite oral. As ervas testadas incluíram aloe vera, raiz de althaea, cúrcuma, camomila, vinagre de uva, água de rosas, suco de frutas/vegetais e extrato de amoreira. As intervenções variaram em frequência e duração, mas mostraram resultados positivos, reduzindo a intensidade da mucosite oral, dor e outros sintomas. Algumas intervenções foram tão eficazes quanto tratamentos convencionais como a clorexidina. Conclusão: a pesquisa sugere que abordagens herbais podem ser benéficas no manejo da mucosite oral em pacientes com câncer, mas mais estudos são necessários para confirmar esses resultados.

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Biografia do Autor

Fatma Özkan Tuncay, Sivas Cumhuriyet Üniversitesi

Graduated from the nursing school in 2000. In 2004, she completed her master's degree in internal medicine nursing and in 2013 she completed her doctorate program. She worked as a clinical nurse at Cumhuriyet University Medical Faculty Hospital between 1996-2000. Her research studies focused on neurological diseases such as stroke, MS and caregivers of individuals with neurological diseases. She is currently working as a nurse faculty member at Sivas Cumhuriyet University, Department of Internal Medicine.

Sena Nur Yapar, Sivas Cumhuriyet Üniversitesi

In 2017, she graduated from Uludağ University Faculty of Nursing. In 2021, she completed Cumhuriyet University Institute of Health Sciences internal medicine nursing master's program. She is currently continuing her PhD program in internal medicine nursing at Cumhuriyet University Institute of Health Sciences. Since 2017, she has been working as a clinical service nurse at Sivas Numune Hospital.

Referências

ArbabiSarjou A, Khamar M, Sasanpour P, Kiani F. The Effect of Self-Care Training on the Severity of Oral Mucositis in Breast Cancer Patients Undergoing Chemotherapy. Med-Surg Nurs J. 2021;10(4):e123386. DOI: 10.5812/msnj.123386

World Health Organization (WHO). Cancer [Internet]. 2019 [April 12, 2023]. Accessed: https://www.who.int/health-topics/cancer

Mohammadi F, Oshvandi K, Kamallan SR, Khazaei S, Ranjbar H, Ahmadi‐Motamayel F, vd. Effectiveness of Sodium Bicarbonate and Zinc Chloride Mouthwashes in the Treatment of Oral Mucositis and Quality of Life in Patients with Cancer Under Chemotherapy. Nurs Open. Mayıs 2022;9(3):1602-11. DOI: 10.1002/nop2.1168

Global World Cancer Research Fund International. Global Cancer Data by country [Internet]. 2023 [April 12, 2023]. Accessed: https://www.wcrf.org/cancer-trends/global-cancer-data-by-country/

Askarifar M, Lakdizaji S, Ramzi M, Rahmani A, Jabbarzadeh F. The Effects of Oral Cryotherapy on Chemotherapy-Induced Oral Mucositis in Patients Undergoing Autologous Transplantation of Blood Stem Cells: A Clinical Trial. Iran Red Crescent Med J. 2016;18(4):e24775. DOI: 10.5812/ircmj.24775

Ali YM, El–Kady MS, Ali HS, Abdelatief DAA, Abdelslam SN. Effect of Educational Guidelines on Reducing Chemotherapy Induced Oral Mucositis Based on Patients’ Needs Assessment. Int J Res Pharm Sci. 2020;11(SPL4):2570-4. DOI: 10.26452/ijrps.v11iSPL4.4514

Kostak MA, Semerci̇ R, Eren T, Kocaaslan EN, Yıldız F. Effects of Oral Health Care Education on the Severity of Oral Mucositis in Pediatric Oncology Patients. Turk J Oncol. 2020;35(4):422-9. DOI: 10.5505/tjo.2020.2366

Ghorbani F, Yazdanian M, Tahmasebi E, Izadi M, Mofid B, Varpaei HA. Effect of Ozonated Water on Oral Mucositis and Pain Induced by Head and Neck Radiotherapy: A Cross-Sectional Study. Arch Neurosci. 2021;8(4):e118914. DOI: 10.5812/ans.118914

Afrasiabifar A, Dekhordi NJ, Mosavi A, Mozaffari MAN, Bani ZAB. Oral Mucositis: Examining the Combined Solution of Grape Vinegar and Rose Water Versus Chlorhexidine Mouthwash. Clin J Oncol Nurs. 2020;24(6):E71-8. DOI: 10.1188/20.CJON.E71-E78

Avcı Ş, Sarı HY. Effect of an Evidence-Based Nursing Intervention on the Diagnosis of Oral Mucositis in the Pediatric Stem Cell Transplant Unit. Asia-Pac J Oncol Nurs. 2019;6(3):292-9. DOI: 10.4103/apjon.apjon_5_19

Toygar I, Yeşilbalkan ÖU. Determining the Non-Pharmacological Methods Using to Cope with Radiation-Related Oral Mucositis in Patients with Head and Neck Cancer. Nurs Pract Today. 2019;6(3):116-22. https://publish.kne-publishing.com/index.php/NPT/article/view/1254

Bai RR. Effectiveness of Oral Ice Cube Application on Prevention of Oral Mucositis Among Cancer Patients Who Receive Chemotherapy. Innov J Nurs Heal. 2019;5(3):38-43. DOI: 10.31690/ijnh/39

Chan CWH, Law BMH, Wong MMH, Chan DNS, Ng MSN, So WKW, vd. Oral Mucositis Among Chinese Cancer Patients Receiving Chemotherapy: Effects and Management Strategies. Asia Pac J Clin Oncol. Nisan 2021;17(2):e10-7. DOI: 10.1111/ajco.13349

Ghorbani MS, Taghadosi M, Shariat A, Akbari H. Effects of Althaea Root Extract on Alleviating Chemotherapy-Induced Stomatitis Pain: A Randomized Controlled Clinical Trial. J Client-Centered Nurs Care. 2018;4(1):37-44. https://www.sid.ir/FileServer/JE/50002120180105

Karabey T, Karagözoğlu Ş, Aygün N, Sümer Z. The Effect of Oral Care with Black Mulberry Extract on Oral Mucositis, Dry Mouth, and Weight Gain in Patients with Cancer. Clin J Oncol Nurs. 2022;26(6):636-42. DOI: 10.1188/22.CJON.636-642

Chang HP, Huang MC, Lei YP, Chuang YJ, Wang CW, Sheen LY. Phytochemical-Rich Vegetable and Fruit Juice Alleviates Oral Mucositis During Concurrent Chemoradiotherapy in Patients with Locally Advanced Head and Neck Cancer. J Tradit Complement Med. 2022;12(5):488-98. DOI: 10.1016/j.jtcme.2022.03.004

Ghorbani MS, Taghadosi M, Akbari H, Sharifi M. Effect of Hydroalcoholic Extract of Althaea Officinalis Root on Improving Chemotherapy-Induced Stomatitis: A Randomized, Double-Blind, Clinical Trial. Nurs Midwifery Stud. 2019;8(1):14-20. DOI: 10.4103/nms.nms_42_18

AbdElwadoud AM, Hassanein SM, El-Deen DS, Abdou I. Using Chamomile for Alleviating Oral Mucositis Among Patients with Head and Neck Cancer Receiving Radiotherapy. Egypt Nurs J. 2019;16(3):186. DOI: 10.4103/ENJ.ENJ_12_20

Lalla RV, Bowen J, Barasch A, Elting L, Epstein J, Keefe DM, vd. MASCC/ISOO Clinical Practice Guidelines for the Management of Mucositis Secondary to Cancer Therapy. Cancer. 2020;120(10):1453-61. DOI: 10.1002/cncr.28592

Kara H, Arıkan F, Kartöz F, Şahin AFK. Nurse-Led Oral Mucositis Management: Impact on Health Outcomes of Patients Receiving Radiotherapy for Head and Neck Cancer and Lung Cancer: A Prospective Study. 2022; DOI: 10.21203/rs.3.rs-1734361/v1

Harman M, Ovayolu N, Ovayolu ÖU. The Effect of Three Different Solutions on Preventing Oral Mucositis in Cancer Patients Undergoing Stem Cell Transplantation: A Non-Randomized Controlled Trial: A Turkish Study. J Pak Med Assoc. 2019;69(6):811-6. https://acikerisim.medipol.edu.tr/xmlui/handle/20.500.12511/776

Badr LK, El Asmar R, Hakim S, Saad R, Merhi R, Zahreddine A, vd. The Efficacy of Honey or Olive Oil on the Severity of Oral Mucositis and Pain Compared to Placebo (standard Care) in Children with Leukemia Receiving Intensive Chemotherapy: A Randomized Controlled Trial (RCT). J Pediatr Nurs. 2023;70:e48-53. DOI: 10.1016/j.pedn.2022.12.003

Ambili R, Ramadas K, Nair LM, Raj D, Nazeer F, George PS, vd. Efficacy of a Herbal Mouthwash for Management of Periodontitis and Radiation-Induced Mucositis–a Consolidated Report of Two Randomized Controlled Clinical Trials. J Ayurveda Integr Med. 2023;14(6):100791. DOI: 10.1016/j.jaim.2023.100791

Safarzadeh S, Shirban F, Bagherniya M, Sathyapalan T, Sahebkar A. The Effects of Herbal Medicines on Cancer Therapy Oral Mucositis: A Literature Review. Phytother Res. Ocak 2022;36(1):243-65. DOI: 10.1002/ptr.7308

Baharvand M, Jafari S, Mortazavi H. Herbs in Oral Mucositis. J Clin Diagn Res JCDR. 2017;11(3):ZE05. DOI: 10.7860/JCDR/2017/21703.9467

Cochrane Library. Cochrane Handbook for Systematic Reviews of Interventions [Internet]. 2023 [April 15, 2023]. Accessed: https://training.cochrane.org/handbook/current

Cochrane Library. Rob 2: A Revised Cochrane Risk-of-Bias Tool for Randomized Trials | Cochrane Bias [İnternet]. 2019 [December 1, 2023]. Accessed: https://methods.cochrane.org/bias/resources/rob-2-revised-cochrane-risk-bias-tool-randomized-trials

Kalav S, Çetin AA, Bektaş H. The Effect of Oral Hygiene Practices in Patients with Stroke: Systematic Review. Turk Klin J Nurs Sci. 2020;12(3). DOI: 10.5336/nurses.2020-74729

Mansouri P, Haghighi M, Beheshtipour N, Ramzi M. The Effect of Aloe Vera Solution on Chemotherapy-Induced Stomatitis in Clients with Lymphoma and Leukemia: A Randomized Controlled Clinical Trial. Int J Community Based Nurs Midwifery. 2016;4(2):119. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876780/

David MPR, Shree MKT. Effectiveness of Turmeric Mouthwash and Sodium Bicarbonate Mouthwash to Reduce Oral Mucositis among Patient Undergoing Radiation Therapy. Sch Int J Tradit Complement Med. 2019;2(7):124-7. DOI: 10.36348/SIJTCM.2019.v02i07.001

McCaffery M, Beebe A. The Numeric Pain Rating Scale Instructions. Pain Clin Man Nurs Pract. 1989 http://nperesource.casn.ca/wp-content/uploads/2017/02/Numeric-Pain-Rating-Scale-Instructions.pdf

Bjarnason GA, MacKenzie RG, Nabid A, Hodson ID, El-Sayed S, Grimard L, vd. Comparison of Toxicity Associated with Early Morning Versus Late Afternoon Radiotherapy in Patients with Head-and-Neck Cancer: A Prospective Randomized Trial of the National Cancer Institute of Canada Clinical Trials Group (HN3). Int J Radiat Oncol Biol Phys. 2009;73(1):166-72. DOI: 10.1016/j.ijrobp.2008.07.009

Kushner JA, Lawrence HP, Shoval I, Kiss TL, Devins GM, Lee L, vd. Development and Validation of a Patient-Reported Oral Mucositis Symptom (PROMS) Scale. J Can Dent Assoc. 2008;74(1):p59-59j. https://search.ebscohost.com/login.aspx?direct=true&profile=ehost&scope=site&authtype=crawler&jrnl=07098936&AN=30006141&h=90yvGQW9sUKXaPJ%2Fbfdg%2FgBlUbQYIiOfyH6m%2FAD1NtS3OzXHILHi2%2FQGeiNzQmy7%2B8LDX0X%2FMlxE%2FP4iQx5Ijg%3D%3D&crl=c

Bjordal K, Ahlner-Elmqvist M, Tollesson E, Jensen AB, Razavi D, Maher EJ, vd. Development of a European Organization for Research and Treatment of Cancer (EORTC) Questionnaire Module to be Used in Quality of Life Assessments in Head and Neck Cancer Patients. Acta Oncol. Ocak 1994;33(8):879-85. DOI: 10.3109/02841869409098450

Eilers J, Berger AM, Petersen MC. Development, Testing, and Application of the Oral Assessment Guide. Oncology Nursing Society; 1988; p.325-30. https://experts.nebraska.edu/en/publications/development-testing-and-application-of-the-oral-assessment-guide

Guberti M, Botti S, Caffarri C, Cavuto S, Savoldi L, Fusco A, vd. Efficacy and Safety of a Colostrum- and Aloe Vera-Based Oral Care Protocol to Prevent and Treat Severe Oral Mucositis in Patients Undergoing Hematopoietic Stem Cell Transplantation: A Single-Arm Phase Ii Study. Ann Hematol. Ekim 2022;101(10):2325-36. DOI: 10.1007/s00277-022-04934-4

Alkhouli M, Laflouf M, Alhaddad M. Efficacy of Aloe-Vera Use for Prevention of Chemotherapy-Induced Oral Mucositis in Children with Acute Lymphoblastic Leukemia: A Randomized Controlled Clinical Trial. Compr Child Adolesc Nurs. 02 Ocak 2021;44(1):49-62. DOI: 10.1080/24694193.2020.1727065

Karbasizade S, Ghorbani F, Darestani NG, Mansouri-Tehrani MM, Kazemi AH. Comparison of Therapeutic Effects of Statins and Aloe Vera Mouthwash on Chemotherapy Induced Oral Mucositis. Int J Physiol Pathophysiol Pharmacol. 2021;13(4):110. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446774/

Sahebjamee M, Mansourian A, Hajimirzamohammad M, Zadeh MT, Bekhradi R, Kazemian A, vd. Comparative Efficacy of Aloe Vera and Benzydamine Mouthwashes on Radiation-Induced Oral Mucositis: A Triple-Blind, Randomised, Controlled Clinical Trial. Oral Health Prev Dent. 2015;13(4):309-15. DOI: 10.3290/j.ohpd.a33091

Normando AGC, De Menêses AG, De Toledo IP, Borges GÁ, De Lima CL, Dos Reis PED, vd. Effects of Turmeric and Curcumin on Oral Mucositis: A Systematic Review. Phytother Res. Mayıs 2019;33(5):1318-29. DOI: 10.1002/ptr.6326

Soni TP, Gupta AK, Sharma LM, Singhal H, Sharma S, Gothwal RS. A Randomized, Placebo-Controlled Study to Evaluate the Effect of Bio-Enhanced Turmeric Formulation on Radiation-Induced Oral Mucositis. Orl. 2022;84(2):103-13. DOI: 10.1159/000516577

Thomas PL, Kang HK, Rishi KS. Randomized Control Study of the Effects of Turmeric Mouthwash on Oral Health Status, Treatment-Induced Mucositis, and Associated Oral Dysfunctions Among Patients with Head and Neck Cancer. Cancer Nurs. 2023;46(1):36-44. DOI: 10.1097/NCC.0000000000001149

Elhadad MA, El‐Negoumy E, Taalab MR, Ibrahim RS, Elsaka RO. The Effect of Topical Chamomile in the Prevention of Chemotherapy‐Induced Oral Mucositis: A Randomized Clinical Trial. Oral Dis. Ocak 2022;28(1):164-72. DOI: 10.1111/odi.13749

Reis PEDD, Ciol MA, de Melo NS, Figueiredo PT de S, Leite AF, Manzi N de M. Chamomile Infusion Cryotherapy to Prevent Oral Mucositis Induced by Chemotherapy: A Pilot Study. Support Care Cancer. 2016;24:4393-8. DOI: 10.1007/s00520-016-3279-y

Ameri A, Heydarirad G, Choopani R, Poshtmahi S, Ameri P, Talebi F, vd. Sumac-Rose Water Mouthwash Versus Benzydamine to Prevent Radiation-Induced Oral Mucositis in Head and Neck Cancers: A Phase Ii Randomized Trial. J Cancer Res Clin Oncol. 2023;1-13. DOI: 10.1007/s00432-023-04687-1

Korkut S, Karadağ S, Çınar SL. The Effect of Oral Care with Black Mulberry Syrup on Oral Mucositis in Patients with COPD: A Mixed Study. Altern Ther. 2021. http://www.alternative-therapies.com/oa/pdf/6430.pdf

Doğan P, Tarhan M, Kürklü A. Effectiveness of Black Mulberry Molasses in Prevention of Radiotherapy-Induced Oral Mucositis: A Randomized Controlled Study in Head and Neck Cancer Patients. The Journal of Alternative and Complementary Medicine. 2023;11(2):1591-602. DOI: 10.1089/acm.2016.0425

Fischer L. Black Mulberry Extract Shows Efficacy in Oral Mucositis Management for Patients Receiving Chemotherapy. Oncol Nurs News. 2022;NA-NA. https://go.gale.com/ps/i.do?p=HRCA&sw=w&issn=&v=2.1&it=r&id=GALE%7CA762612137&sid=googleScholar&linkaccess=abs

Sarı SY, Beduk Esen CS, Yazici G, Yuce D, Cengiz M, Ozyigit G. Do Grape and Black Mulberry Molasses Have an Effect on Oral Mucositis and Quality of Life in Patients with Head and Neck Cancer? Support Care Cancer. 2022;30:327-36. DOI: 10.1007/s00520-021-06411-6

Ebrahim AA, Ahmed ES, Eltayeb AA, Sayed EH. Role of Chlorhexidine in Preventing Mucositis Among Ventilated Children at Pediatric Intensive Care Unit. Assiut Sci Nurs J. 2022;10(28.):123-34. DOI: 10.21608/ASNJ.2022.121442.1323