Therapeutic use of medicinal cannabis in people with degenerative neurological disease             /              Uso terapêutico da cannabis medicinal em pessoas com doença neurológica degenerativa

Roni Robson da Silva; Leandro Andrade da  Silva; Luiz Otavio Pereira dos  Santos; Alexandro Alves  Ribeiro; Fabrícia Martins  Sales; Icaro Ferracini  Alencar

doi:10.9789/2175-5361.rpcfo.v14.11492

Authors

Roni Robson da Silva Universidade Veiga de Almeida https://orcid.org/0000-0001-6010-6438
Leandro Andrade da Silva Universidade Veiga de Almeida https://orcid.org/0000-0003-3213-5527
Luiz Otavio Pereira dos Santos Universidade de Guarulhos https://orcid.org/0000-0002-0295-4890
Alexandro Alves Ribeiro Universidade Estácio de Sá https://orcid.org/0000-0002-6531-1753
Fabrícia Martins Sales Universidade do Estado do Rio de Janeiro https://orcid.org/0000-0002-8693-874X
Icaro Ferracini Alencar Universidade Iguaçu UNIG https://orcid.org/0000-0003-3852-7767

DOI:

https://doi.org/10.9789/2175-5361.rpcfo.v14.11492

Keywords:

Cannabis, Cannabis sativa, Medical Marijuana, Nervous System Diseases, Chronic pain, Chronic Disease

Abstract

Various therapeutic uses of cannabis and its derivatives have been postulated from pre clinical investigation. Cannabis has been used for medicinal purposes for many years, however, the positive and negative effects on Parkinson's, multiple sclerosis and Alzheimer's disease are still largely unknown. Objective: to present the state of the art of publications expressed in the world Scientific literature on the subject, as well as to identify the therapeutic benefits of medicinal cannabis in the treatment of neurodegenerative diseases, specifically, Parkinson's diseases, multiple sclerosis and Alzheimer's. Method: This is an integrative literature review, whose data search was performed in virtual librares. Web of Science, Scopus, Medline, Lilacs, Cochrane Library and Scielo from August to October 2021. Results: 158 articles were found. Twenty-three articles were selected to be read in full and 8 met the criteria of this review. Conclusion: Evidence shows that although increasingly prescribed or authorized, medical cannabis or Cannabinoids for chronic pain remain controversial for many physicians.

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Author Biographies

Roni Robson da Silva, Universidade Veiga de Almeida

Enfermeiro. Mestrando em enfermagem da USP.

Leandro Andrade da Silva, Universidade Veiga de Almeida

Professor adjunto do Centro Universitário Augusto Motta.

Luiz Otavio Pereira dos Santos, Universidade de Guarulhos

Enfermeiro. Doutorando em Enfermagem.

Alexandro Alves Ribeiro, Universidade Estácio de Sá

Doutor em enfermagem.

Fabrícia Martins Sales, Universidade do Estado do Rio de Janeiro

Mestra em enfermagem.

Icaro Ferracini Alencar , Universidade Iguaçu UNIG

Enfermeiro.

References

Silva RR da, Silva LA da. Psychosocial load and burnout syndrome in healthcare professionals in the fight against COVID-19 pandemic. Rev. Pesqui. (Univ. Fed. Estado Rio J., Online). [Internet]. 2021 [cited 2021 nov 18];13. Available from: https://doi.org/10.9789/2175-5361.rpcfo.v13.11097.

Silva RR da, Neves MP das, Silva LA da, Silva MVG, Hipólito RL, Marta CB. Consumo de drogas psicoativas em contexto de sexual entre homens gays como fator de risco para transmissão de HIV/Aids. Glob Acad Nurs. [Internet]. 2020 [acesso em 18 de novembro 2021];1(3). Disponível em: https://doi.org/10.5935/2675-5602.20200057.

Silva RR da, Silva LA da, Souza MVL de, Silva MVG da, Neves MP das, Vargas D, et al. Minority gender stress and its effects on mental health as a risk factor for depression in transgender persons: Literature review. Res Soc Dev. [Internet]. 2021 [cited 2021 nov 18];10(12):e51610313693. Available from: https://doi.org/10.33448/rsd-v10i3.13693.

Orjuela-Rojas JM, Orjuela XG, Serna SO. Medicinal cannabis: knowledge, beliefs, and attitudes of colombian psychiatrists. J cannabis Res. 2021 [cited 2021 nov 18];3(1). Available from: https://doi.org/10.1186/s42238-021-00083-z.

Silva IN de CJAG da. Estimativa 2020: incidência de câncer no Brasil TT - estimate/2020 ¬ cancer incidence in Brazil TT. [Internet]. 2020. p. 120. Disponível em: https://www.inca.gov.br/sites/ufu.sti.inca.local/files//media/document//estimativa-2020-incidencia-de-cancer-no-brasil.pdf.

Fowler CJ. The endocannabinoid system - current implications for drug development. J. intern. med. [Internet]. 2021 [cited 2021 nov 18];290(1). Available from: https://dx.doi.org/10.1111/joim.13229.

Boland EG, Bennett MI, Allgar V, Boland JW. Cannabinoids for adult cancer-related pain: systematic review and meta-analysis. BMJ support. palliat. care (Online). [Internet]. 2020 [cited 2021 nov 18];10(1). Available from: http://dx.doi.org/10.1136/bmjspcare-2019-002032.

Kaufmann CN, Kim A, Miyoshi M, Han BH. Patterns of medical cannabis use among older adults from a cannabis dispensary in New York State. Cannabis Cannabinoid Res. [Internet]. 2020 [cited 2021 nov 18];5. Available from: http://doi.org/10.1089/can.2020.0064.

Chapman EJ, Edwards Z, Boland JW, Maddocks M, Fettes L, Malia C, et al. Practice review: evidence-based and effective management of pain in patients with advanced cancer. Palliat. med. [Internet]. 2020 [cited 2021 nov 18];34(4). Available from: https://doi.org/10.1177/0269216319896955.

Daris B, Verboten MT, Knez Z, Ferk P. Cannabinoids in cancer treatment: Therapeutic potential and legislation. Bosn. j. basic med. sci. (Print). [Internet]. 2019 [cited 2021 nov 18];19(1). Available from: https://doi.org/10.17305/bjbms.2018.3532.

Tran T, Kavuluru R. Social media surveillance for perceived therapeutic effects of cannabidiol (CBD) products. Int. j. drug policy. [Internet]. 2020 [cited 2021 nov 18];77. Available from: https://doi.org/10.1016/j.drugpo.2020.102688.

Lowe H, Toyang N, Steele B, Bryant J, Ngwa W, Nedamat K. The current and potential application of medicinal cannabis products in dentistry. Dent. j. [Internet]. 2021 [cited 2021 nov 18];9(9). Available from: https://doi.org/10.3390/dj9090106.

Fehniger J, Brodsky AL, Kim A, Pothuri B. Medical marijuana utilization in gynecologic cancer patients. Gynecol. Oncol. Rep. [Internet]. 2021 [cited 2021 nov 18];37. Available from: https://doi.org/10.1016/j.gore.2021.100820.

Argueta DA, Ventura CM, Kiven S, Sagi V, Gupta K. A balanced approach for cannabidiol use in chronic pain. Front. pharmacol. [Internet]. 2020 [cited 2021 nov 18];11. Available from: https://doi.org/10.3389/fphar.2020.00561.

Moher D. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann. intern. med. [Internet]. 2009 [cited 2021 nov 18];151(4). Available from: https://doi.org/10.7326/0003-4819-151-4-200908180-00135.

Granholm A, Alhazzani W, Møller MH. Use of the GRADE approach in systematic reviews and guidelines. Br. j. anaesth. [Internet]. 2019 [cited 2021 nov 18];123(5). Available from: https://doi.org/10.1016/j.bja.2019.08.015.

Russo EB. Cannabis Therapeutics and the future of neurology. Front. integr. neurosci. [Internet]. 2018 [cited 2021 nov 18];3(2). Available from: https://doi.org/10.3389/fnint.2018.00051.

Gowran A, Noonan J, Campbell, VA. The multiplicity of action of cannabinoids: implications for treating neurodegeneration. CNS neuroscience & therapeutics (Online), 1755-5949. [Internet]. 2010 [cited 2021 nov 18];17(6). Available from: https://doi.org/10.1111/j.1755-5949.2010.00195.x.

Murnion B. Cannabis medicinal. Aust. prescr. [Internet]. 2015 [cited 2021 nov 18];38(6). Available from: https://doi.org/10.18773/austprescr.2015.072.

Baker D, Jackson SJ, Pryce G. Cannabinoid control of neuroinflammation related to multiple sclerosis. Br. j. pharmacol. [Internet]. 2009 [cited 2021 nov 18];152(5). Available from: https://doi.org/10.1038/sj.bjp.0707458.

Nachnani R, Raup-Konsavage WM, Vrana KE. The pharmacological case for cannabigerol. J. pharmacol. exp. ther. [Internet]. 2021 [cited 2021 nov 18];376(2). Available from: https://doi.org/10.1124/jpet.120.000340.

Pratt M, Stevens A, Thuku M, Butler C, Skidmore B, Wieland LS, et al. Benefits and harms of medical cannabis: a scoping review of systematic reviews. Syst. rev. [Internet]. 2019 [cited 2021 nov 18];8(320). Available from: https://doi.org/10.1186/s13643-019-1243-x.

Dzierzanowski T. Prospects for the use of cannabinoids in oncology and palliative care practice: a review of the evidence. Cancers. [Internet]. 2019 [cited 2021 nov 18];11(2). Available from: https://doi.org/10.3390/cancers11020129.

Bolshakova M, Bluthenthal R, Sussman S. Opioid use and misuse: health impact, prevalence, correlates and interventions. Psychol. health. [Internet]. 2019 [cited 2021 nov 18];34(9). Available from: https://doi.org/10.1080/08870446.2019.1622013.

Noori A, Miroshnychenko A, Shergill Y, Atefeh N, Miroshnychenko A, Shergill Y, et al. Opioid-sparing effects of medical cannabis or cannabinoids for chronic pain: a systematic review and meta-analysis of randomised and observational studies. BMJ Open. [Internet]. 2021 [cited 2021 nov 18];11:e047717. Available from: https://doi.org/10.1136/bmjopen-2020-047717.

Amato L, Minozzi S, Mitrova Z, Parmelli E, Saulle R, Cruciani F, et al. Systematic review of safeness and therapeutic efficacy of cannabis in patients with multiple sclerosis, neuropathic pain, and in oncological patients treated with chemotherapy. Epidemiol. prev. [Internet]. 2017 [cited 2021 nov 18];41(5-6). Available from: https://doi.org/10.19191/EP17.5-6.AD01.069.

Braun IM, Wright A, Peteet J, Meyer FL, Yuppa DP, Bolcic-Jankovic D, et al. Medical oncologists' beliefs, practices, and knowledge regarding marijuana used therapeutically: a nationally representative survey study. J. clin. oncol. [Internet]. 2018 [cited 2021 nov 18];36(19). Available from: https://doi.org/10.1200/JCO.2017.76.1221.

Pryce G, Riddall DR, Selwood DL, Giovannoni G, Bake D. Neuroprotection in experimental autoimmune encephalomyelitis and progressive multiple sclerosis by cannabis-based cannabinoids. J. neuroimmune pharmacol. [Internet]. 2015 [cited 2021 nov 18];10. Available from: https://doi.org/10.1007/s11481-014-9575-8.

Ananth P, Ma C, Al-Sayegh H, Kroon L, Klein V, Wharton C, et al. Provider perspectives on use of medical marijuana in children with cancer. Pediatrics. [Internet]. 2018 [cited 2021 nov 18];141(1): e20170559. Available from: https://doi.org/10.1542/peds.2017-0559.

Kim A, Kaufmann CN, Ko R, Li Z, Han BH. Patterns of medical cannabis use among cancer patients from a medical cannabis dispensary in New York State. J. palliat. med. [Internet]. 2019 [cited 2021 nov 18];22(10). Available from: https://doi.org/10.1089/jpm.2018.0529.

Good P, Haywood A, Gogna G, Martin J, Yates P, Greer R, et al. Oral medicinal cannabinoids to relieve symptom burden in the palliative care of patients with advanced cancer: a double-blind, placebo controlled, randomised clinical trial of efficacy and safety of cannabidiol (CBD). BMC palliat. care. [Internet]. 2019 [cited 2021 nov 18];18(1). Available from: https://dx.doi.org/10.1186/s12904-019-0494-6.

Lee C, Round JM, Klarenbach S, Hanlon JG, Hyshka E, Dyck JRB, et al. Gaps in evidence for the use of medically authorized cannabis: Ontario and Alberta, Canada. Harm reduct. j. [Internet]. 2021 [cited 2021 nov 18];18(1). Available from: https://doi.org/10.1186/s12954-021-00509-0.

Noori A, Busse JW, Sadeghirad B, Siemieniuk RA, Wang L, Couban R, et al. Individual opioids, and long-versus short-acting opioids, for chronic noncancer pain Protocol for a network meta-analysis of randomized controlled trials. Medicine (Baltimore). [Internet]. 2019 [cited 2021 nov 18];98(43). Available from: http://dx.doi.org/10.1097/MD.0000000000017647.

Karanges EA, Suraev A, Elias N, Manocha R, McGregor IS. Knowledge and attitudes of Australian general practitioners towards medicinal cannabis: a cross-sectional survey. BMJ Open. [Internet]. 2018 [cited 2021 nov 18];8(7):e022101. Available from: http://dx.doi.org/10.1136/bmjopen-2018-022101.

Montero ON, Arevalo RI, Nuñez GS, Viteri A, Simancas RD. Therapeutic use of cannabis and cannabinoids: an evidence mapping and appraisal of systematic reviews. BMC Complement med ther. [Internet]. 2020 [cited 2021 nov 18];20(12). Available from: https://doi.org/10.1186/s12906-019-2803-2.

Breijyeh Z, Jubeh B, Bufo SA, Karaman R, Scrano L. Cannabis: a toxin-producing plant with potential therapeutic uses. Toxins (Basel). [Internet]. 2021 [cited 2021 nov 18];13(2). Available from: https://doi.org/10.3390/toxins13020117.

Buchwald D, Brønnum D, Melgaard D, Leutscher P. Living with a hope of survival is challenged by a lack of clinical evidence: an interview study among cancer patients using cannabis-based medicine. J. palliat. med. [Internet]. 2019 [cited 2021 nov 18];23(8). Available from: https://dx.doi.org/10.1089/jpm.2019.0298.

Allem JP, Escobedo P, Dharmapuri L. Cannabis surveillance with twitter data: emerging topics and social bots. Am. j. public health (1971). [Internet]. 2020 [cited 2021 nov 18];110(3). Available from: https://dx.doi.org/10.2105/AJPH.2019.305461.

Ian M, Pawasarat EM, Schultz JC, Frisby SM, Angelo SS, Hardy TWBK. The efficacy of medical marijuana in the treatment of cancer-related pain. J. palliat. med. [Internet]. 2020 [cited 2021 nov 18];23(6). Available from: http://doi.org/10.1089/jpm.2019.0374.